Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the ron receptor

Ron (the receptor for Macrophage Stimulating Protein) has never been implicated before in human malignancies or in cell transformation. In this report we show that Ron can acquire oncogenic potential by means of two amino acid substitutions-D1232V and M1254T-affecting highly conserved residues in th...

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Bibliographic Details
Published in:	Oncogene Vol. 17; no. 6; pp. 741 - 749
Main Authors:	Santoro, Massimo Mattia, Penengo, Lorenza, Minetto, Marta, Orecchia, Sara, Cilli, Michele, Gaudino, Giovanni
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing 13.08.1998 Nature Publishing Group
Subjects:	3T3 Cells Amino acids Animals Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - genetics COS Cells Drosophila Proteins Fibroblasts Fundamental and applied biological sciences. Psychology Genetic transformation HeLa Cells Humans JNK Mitogen-Activated Protein Kinases Kinases Lung Neoplasms - pathology Macrophages MAP kinase Mastocytosis Metastases Metastasis Mice Mice, Nude Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinases Molecular and cellular biology Multiple endocrine neoplasia Mutants Mutation Neoplasm Metastasis Neuroendocrine tumors Oncogenes Phenotype Phosphorylation Point Mutation Protein Kinases - metabolism Protein-tyrosine kinase Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-ret Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Ret protein Sarcoma, Experimental - pathology Signal Transduction Substrate specificity Tumorigenesis Tumors Human Macrophage activating factor Gene Enzyme Transferases Point mutation Tumor progression Metastasis Cell transformation Carcinogenesis Protein-tyrosine kinase Biological receptor
ISSN:	0950-9232, 1476-5594
Online Access:	Get full text
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