Ligand cross-feeding resolves bacterial vitamin B12 auxotrophies
Cobalamin (vitamin B 12 , herein referred to as B 12 ) is an essential cofactor for most marine prokaryotes and eukaryotes 1 , 2 . Synthesized by a limited number of prokaryotes, its scarcity affects microbial interactions and community dynamics 2 – 4 . Here we show that two bacterial B 12 auxotroph...
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| Vydáno v: | Nature (London) Ročník 629; číslo 8013; s. 886 - 892 |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
23.05.2024
Nature Publishing Group |
| Témata: | |
| ISSN: | 0028-0836, 1476-4687, 1476-4687 |
| On-line přístup: | Získat plný text |
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| Shrnutí: | Cobalamin (vitamin B
12
, herein referred to as B
12
) is an essential cofactor for most marine prokaryotes and eukaryotes
1
,
2
. Synthesized by a limited number of prokaryotes, its scarcity affects microbial interactions and community dynamics
2
–
4
. Here we show that two bacterial B
12
auxotrophs can salvage different B
12
building blocks and cooperate to synthesize B
12
. A
Colwellia
sp. synthesizes and releases the activated lower ligand α-ribazole, which is used by another B
12
auxotroph, a
Roseovarius
sp., to produce the corrin ring and synthesize B
12
. Release of B
12
by
Roseovarius
sp. happens only in co-culture with
Colwellia
sp. and only coincidently with the induction of a prophage encoded in
Roseovarius
sp. Subsequent growth of
Colwellia
sp. in these conditions may be due to the provision of B
12
by lysed cells of
Roseovarius
sp. Further evidence is required to support a causative role for prophage induction in the release of B
12
. These complex microbial interactions of ligand cross-feeding and joint B
12
biosynthesis seem to be widespread in marine pelagic ecosystems. In the western and northern tropical Atlantic Ocean, bacteria predicted to be capable of salvaging cobinamide and synthesizing only the activated lower ligand outnumber B
12
producers. These findings add new players to our understanding of B
12
supply to auxotrophic microorganisms in the ocean and possibly in other ecosystems.
Two species of auxotrophic marine bacteria are shown to share precursors to synthesize the essential cofactor vitamin B
12
, and such ligand cross-feeding may be a common phenomenon in the ocean and other ecosystems. |
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| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ISSN: | 0028-0836 1476-4687 1476-4687 |
| DOI: | 10.1038/s41586-024-07396-y |