Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of inflammation and NPC development remains unexplored. To investigate this question, we performed a profile analysis on plasma collected from untreat...

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Bibliographic Details
Published in:Biomarkers Vol. 17; no. 7; pp. 618 - 624
Main Authors: Bourouba, Mehdi, Boukercha, Aziza, Zergoun, Ahmed-Amine, Zebboudj, Abderezak, Elhadjan, Mohamed, Djenaoui, Djamel, Asselah, Fatima, Touil-Boukoffa, Chafia
Format: Journal Article
Language:English
Published: England Informa Healthcare 01.11.2012
Taylor & Francis
Subjects:
Adolescent
Adult
Algeria
biomarker
carcinogenesis
Carcinoma - blood
Carcinoma - pathology
Carcinoma - therapy
Case-Control Studies
Humans
inflammation
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - blood
Nasopharyngeal Neoplasms - pathology
Nasopharyngeal Neoplasms - therapy
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - prevention & control
nitric oxide
Nitric Oxide - blood
Tumor Burden
UCNT
Young Adult
Algeria
ISSN:1354-750X, 1366-5804, 1366-5804
Online Access:Get full text
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Summary:Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of inflammation and NPC development remains unexplored. To investigate this question, we performed a profile analysis on plasma collected from untreated, treated, remissive, cured and relapsing patients. Nitrites were measured to assess NO activity. We observed that increased nitrites concentrations in untreated and relapsing patients associated with tumor development. Moreover, nitrites levels were similar in remissive, cured and healthy individuals. Altogether, our results suggest that NO might be an interesting blood biomarker to monitor tumor growth in NPC patients.
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ISSN:1354-750X
1366-5804
1366-5804
DOI:10.3109/1354750X.2012.706643