Risk Factors for Postdischarge Major Thromboembolism and Mortality in Hospitalized Patients with COVID-19 with Cardiovascular Comorbidities: Insights from the CORE-19 Registry

Coronavirus disease 2019 (COVID-19) is associated with venous and arterial thromboembolism (VTE and ATE) and all-cause mortality (ACM) in hospitalized patients. High-quality data are needed on postdischarge outcomes in patients with cardiovascular disease. To analyze outcomes and identify risk fact...

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Vydáno v:	Thrombosis and haemostasis Ročník 123; číslo 11; s. 1089
Hlavní autoři:	Giannis, Dimitrios, Goldin, Mark, Rahman, Husneara, Sison, Cristina P, Lesser, Martin L, Ngu, Sam, Tsang, James, Qiu, Michael, Sanghani, Shreya, Yeh, Jackson, Matsagkas, Miltiadis, Arnaoutoglou, Eleni, Spyropoulos, Alex C
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Germany 01.11.2023
Témata:	Aftercare Aged COVID-19 - complications Heart Failure - complications Heart Failure - epidemiology Humans Ischemic Stroke Patient Discharge Pulmonary Embolism - epidemiology Pulmonary Embolism - etiology Registries Risk Factors Venous Thromboembolism - etiology
ISSN:	2567-689X, 2567-689X
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Shrnutí:	Coronavirus disease 2019 (COVID-19) is associated with venous and arterial thromboembolism (VTE and ATE) and all-cause mortality (ACM) in hospitalized patients. High-quality data are needed on postdischarge outcomes in patients with cardiovascular disease. To analyze outcomes and identify risk factors for ATE, VTE, and ACM in a high-risk subgroup of hospitalized COVID-19 patients with baseline cardiovascular disease. We investigated postdischarge rates and associated risk factors of ATE, VTE, and ACM in 608 hospitalized COVID-19 patients with coronary artery disease, carotid artery stenosis (CAS), peripheral arterial disease (PAD), or ischemic stroke. Through 90 days postdischarge, outcome rates were: ATE 27.3% (10.2% myocardial infarction, 10.1% ischemic stroke, 13.2% systemic embolism, 12.7% major adverse limb event); VTE 6.9% (4.1% deep vein thrombosis, 3.6% pulmonary embolism); composite of ATE, VTE, or ACM 35.2% (214/608). Multivariate analysis showed significant association between this composite endpoint and age >75 years (odds ratio [OR]: 1.90, 95% confidence interval [CI]: 1.22-2.94, = 0.004), PAD (OR: 3.23, 95% CI: 1.80-5.81, ≤ 0.0001), CAS (OR: 1.74, 95% CI: 1.11-2.75, = 0.017), congestive heart failure (CHF) (OR: 1.84, 95% CI: 1.02-3.35, = 0.044), previous VTE (OR: 3.08, 95% CI: 1.75-5.42, < 0.0001), and intensive care unit (ICU) admission (OR: 2.93, 95% CI: 1.81-4.75, < 0.0001). COVID-19 inpatients with cardiovascular disease experience high rates of ATE, VTE, or ACM through 90 days postdischarge. Age >75 years, PAD, CAS, CHF, previous VTE, and ICU admission are independent risk factors.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2567-689X 2567-689X
DOI:	10.1055/a-2087-3003