R-Ras interacts with filamin a to maintain endothelial barrier function

The molecular mechanisms regulating vascular barrier integrity remain incompletely elucidated. We have previously reported an association between the GTPase R‐Ras and repeat 3 of Filamin A (FLNa). Loss of FLNa has been linked to increased vascular permeability. We sought to determine whether FLNa�...

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Bibliographic Details
Published in:	Journal of cellular physiology Vol. 226; no. 9; pp. 2287 - 2296
Main Authors:	Griffiths, G.S., Grundl, M., Allen III, J.S., Matter, M.L.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2011
Subjects:	Cadherins - metabolism Capillary Permeability Contractile Proteins - metabolism Coronary Vessels - cytology Cytoskeleton - metabolism Endothelial Cells - cytology Endothelial Cells - metabolism Filamins Gene Knockdown Techniques Humans Microfilament Proteins - metabolism Phosphorylation Phosphoserine - metabolism Protein Binding Protein Transport Proto-Oncogene Proteins pp60(c-src) - metabolism ras Proteins - metabolism RNA, Small Interfering - metabolism
ISSN:	0021-9541, 1097-4652, 1097-4652
Online Access:	Get full text
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