Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies

Remission and recovery rates for people with first-episode psychosis (FEP) remain uncertain. To assess pooled prevalence rates of remission and recovery in FEP and to investigate potential moderators. We conducted a systematic review and meta-analysis to assess pooled prevalence rates of remission a...

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Bibliographic Details
Published in:British journal of psychiatry Vol. 211; no. 6; pp. 350 - 358
Main Authors: Lally, John, Ajnakina, Olesya, Stubbs, Brendon, Cullinane, Michael, Murphy, Kieran C., Gaughran, Fiona, Murray, Robin M.
Format: Journal Article
Language:English
Published: Cambridge, UK Cambridge University Press 01.12.2017
Subjects:
Adult
Adults
Humans
Long term
Longitudinal studies
Meta-analysis
Moderators
Outcome Assessment, Health Care - statistics & numerical data
Patients
Psychiatry
Psychosis
Psychotic Disorders - therapy
Recovery
Remission
Remission (Medicine)
Review article
Schizophrenia
Systematic review
India
ISSN:0007-1250, 1472-1465, 1472-1465
Online Access:Get full text
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Summary:Remission and recovery rates for people with first-episode psychosis (FEP) remain uncertain. To assess pooled prevalence rates of remission and recovery in FEP and to investigate potential moderators. We conducted a systematic review and meta-analysis to assess pooled prevalence rates of remission and recovery in FEP in longitudinal studies with more than 1 year of follow-up data, and conducted meta-regression analyses to investigate potential moderators. Seventy-nine studies were included representing 19072 patients with FEP. The pooled rate of remission among 12301 individuals with FEP was 58% (60 studies, mean follow-up 5.5 years). Higher remission rates were moderated by studies from more recent years. The pooled prevalence of recovery among 9642 individuals with FEP was 38% (35 studies, mean follow-up 7.2 years). Recovery rates were higher in North America than in other regions. Remission and recovery rates in FEP may be more favourable than previously thought. We observed stability of recovery rates after the first 2 years, suggesting that a progressive deteriorating course of illness is not typical. Although remission rates have improved over time recovery rates have not, raising questions about the effectiveness of services in achieving improved recovery.
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ISSN:0007-1250
1472-1465
1472-1465
DOI:10.1192/bjp.bp.117.201475