Purification and characterization of a rat liver enzyme that hydrolyzes valaciclovir, the L-valyl ester prodrug of acyclovir

Valaciclovir is an oral prodrug of the antiherpetic agent acyclovir. An enzyme that hydrolyzes valaciclovir to acyclovir, valaciclovir hydrolase (VACVase), was purified from rat liver and characterized. VACVase was a basic (pI 9.4) protein associated with mitochondria. It was monomeric and had a mol...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 270; no. 26; p. 15827
Main Authors:	Burnette, T C, Harrington, J A, Reardon, J E, Merrill, B M, de Miranda, P
Format:	Journal Article
Language:	English
Published:	United States 30.06.1995
Subjects:	Acyclovir - analogs & derivatives Acyclovir - metabolism Amino Acid Sequence Animals Antiviral Agents - metabolism Biotransformation Hydrolases - chemistry Hydrolases - isolation & purification Hydrolases - physiology Liver - enzymology Male Molecular Sequence Data Prodrugs - metabolism Rats Valacyclovir Valine - analogs & derivatives Valine - metabolism
ISSN:	0021-9258
Online Access:	Get more information
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