MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations

Abstract The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA). We previously developed MitoCarta, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome. This...

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Vydané v:	Nucleic acids research Ročník 49; číslo D1; s. D1541 - D1547
Hlavní autori:	Rath, Sneha, Sharma, Rohit, Gupta, Rahul, Ast, Tslil, Chan, Connie, Durham, Timothy J, Goodman, Russell P, Grabarek, Zenon, Haas, Mary E, Hung, Wendy H W, Joshi, Pallavi R, Jourdain, Alexis A, Kim, Sharon H, Kotrys, Anna V, Lam, Stephanie S, McCoy, Jason G, Meisel, Joshua D, Miranda, Maria, Panda, Apekshya, Patgiri, Anupam, Rogers, Robert, Sadre, Shayan, Shah, Hardik, Skinner, Owen S, To, Tsz-Leung, Walker, Melissa A, Wang, Hong, Ward, Patrick S, Wengrod, Jordan, Yuan, Chen-Ching, Calvo, Sarah E, Mootha, Vamsi K
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 08.01.2021
Predmet:	Animals Bayes Theorem Database Issue Databases, Protein Datasets as Topic DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Humans Internet Machine Learning Mass Spectrometry Mice Mitochondria - genetics Mitochondria - metabolism Mitochondrial Membranes - metabolism Mitochondrial Proteins - classification Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Molecular Sequence Annotation Proteome - classification Proteome - genetics Proteome - metabolism Software
ISSN:	0305-1048, 1362-4962, 1362-4962
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Shrnutí:	Abstract The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA). We previously developed MitoCarta, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome. This catalogue was compiled using a Bayesian integration of multiple sequence features and experimental datasets, notably protein mass spectrometry of mitochondria isolated from fourteen murine tissues. Here, we introduce MitoCarta3.0. Beginning with the MitoCarta2.0 inventory, we performed manual review to remove 100 genes and introduce 78 additional genes, arriving at an updated inventory of 1136 human genes. We now include manually curated annotations of sub-mitochondrial localization (matrix, inner membrane, intermembrane space, outer membrane) as well as assignment to 149 hierarchical ‘MitoPathways’ spanning seven broad functional categories relevant to mitochondria. MitoCarta3.0, including sub-mitochondrial localization and MitoPathway annotations, is freely available at http://www.broadinstitute.org/mitocarta and should serve as a continued community resource for mitochondrial biology and medicine.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors wish it to be known that, in their opinion, the first three authors should be regarded as joint First Authors.
ISSN:	0305-1048 1362-4962 1362-4962
DOI:	10.1093/nar/gkaa1011