Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

Lewy bodies commonly occur in Alzheimer's disease, and Alzheimer's disease pathology is frequent in Lewy body diseases, but the burden of co-pathologies across neurodegenerative diseases is unknown. We assessed the extent of tau, amyloid-β, α-synuclein and TDP-43 proteinopathies in 766 aut...

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Vydáno v:	Brain (London, England : 1878) Ročník 141; číslo 7; s. 2181
Hlavní autoři:	Robinson, John L, Lee, Edward B, Xie, Sharon X, Rennert, Lior, Suh, EunRan, Bredenberg, Colin, Caswell, Carrie, Van Deerlin, Vivianna M, Yan, Ning, Yousef, Ahmed, Hurtig, Howard I, Siderowf, Andrew, Grossman, Murray, McMillan, Corey T, Miller, Bruce, Duda, John E, Irwin, David J, Wolk, David, Elman, Lauren, McCluskey, Leo, Chen-Plotkin, Alice, Weintraub, Daniel, Arnold, Steven E, Brettschneider, Johannes, Lee, Virginia M-Y, Trojanowski, John Q
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.07.2018
Témata:	Aged alpha-Synuclein - metabolism Alzheimer Disease - pathology Amyotrophic Lateral Sclerosis - pathology Apolipoprotein E4 - genetics Apolipoprotein E4 - physiology DNA-Binding Proteins Female Humans Inclusion Bodies - pathology Lewy Bodies - pathology Lewy Bodies - physiology Lewy Body Disease - pathology Male Middle Aged Multiple System Atrophy - pathology Neurodegenerative Diseases - physiopathology Pick Disease of the Brain - pathology Prevalence Supranuclear Palsy, Progressive - pathology tau Proteins Tauopathies - physiopathology TDP-43 Proteinopathies - pathology
ISSN:	1460-2156, 1460-2156
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