Insomnia, sleep loss, and circadian sleep disturbances in mood disorders: a pathway toward neurodegeneration and neuroprogression? A theoretical review

The present paper aims at reviewing and commenting on the relationships between sleep and circadian phasing alterations and neurodegenerative/neuroprogressive processes in mood disorder. We carried out a systematic review, according to Preferred Reporting Items for Systematic Reviews and Meta-Analys...

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Vydané v:CNS spectrums Ročník 27; číslo 3; s. 298 - 308
Hlavní autori: Palagini, Laura, Geoffroy, Pierre A., Miniati, Mario, Perugi, Giulio, Biggio, Giovanni, Marazziti, Donatella, Riemann, Dieter
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: New York, USA Cambridge University Press 01.06.2022
Predmet:
Bipolar disorder
Case reports
Circadian rhythm
Emotional disorders
Humans
Hypotheses
Insomnia
Mood Disorders
Neurodegeneration
Neurotoxicity
Oxidative stress
Physiology
Proteins
Public health
Review
Sleep - physiology
Sleep deprivation
Sleep Initiation and Maintenance Disorders
Sleep Wake Disorders
Suicides & suicide attempts
Systematic review
neurodegeneration
sleep loss
Insomnia
neuroprogression
mood disorders
circadian sleep alterations
ISSN:1092-8529, 2165-6509
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Shrnutí:The present paper aims at reviewing and commenting on the relationships between sleep and circadian phasing alterations and neurodegenerative/neuroprogressive processes in mood disorder. We carried out a systematic review, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, in PubMed, PsycINFO, and Embase electronic databases for literature related to mood disorders, sleep disturbances, and neurodegenerative/neuroprogressive processes in relation to (1) neuroinflammation, (2) activation of the stress system, (3) oxidative stress, (4) accumulation of neurotoxic proteins, and (5) neuroprotection deficit. Seventy articles were collectively selected and analyzed. Experimental and clinical studies revealed that insomnia, conditions of sleep loss, and altered circadian sleep may favor neurodegeneration and neuroprogression in mood disorders. These sleep disturbances may induce a state of chronic inflammation by enhancing neuroinflammation, both directly and indirectly, via microglia and astrocytes activation. They may act as neurobiological stressors that by over-activating the stress system may negatively influence neural plasticity causing neuronal damage. In addition, sleep disturbances may favor the accumulation of neurotoxic proteins, favor oxidative stress, and a deficit in neuroprotection hence contributing to neurodegeneration and neuroprogression. Targeting sleep disturbances in the clinical practice may hold a neuroprotective value for mood disorders.
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ISSN:1092-8529
2165-6509
DOI:10.1017/S1092852921000018