Parkin paves the path to antitumor immunity: Expanding Parkin’s role as a tumor suppressor

Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppressor, and its deregulation frequently promotes tumorigenesis....

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Bibliographic Details
Published in:The Journal of clinical investigation Vol. 134; no. 22; pp. 1 - 3
Main Authors: Kim, Hyungsoo, Ronai, Ze’ev A.
Format: Journal Article
Language:English
Published: United States American Society for Clinical Investigation 15.11.2024
Subjects:
Animals
Cancer
Cancer therapies
Care and treatment
CD8-Positive T-Lymphocytes - immunology
Cell cycle
Deregulation
Development and progression
Epigenetics
Health aspects
Humans
Immune response
Immunity (Disease)
Inflammation
Interferon
Ligases
Lymphocytes
Metabolism
Metastasis
Mice
Motility
Mutation
Neoplasms - genetics
Neoplasms - immunology
Parkin protein
Parkinson's disease
Quality control
T cells
Tumor suppressor genes
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - immunology
Tumor Suppressor Proteins - metabolism
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - immunology
Ubiquitin-Protein Ligases - metabolism
ISSN:1558-8238, 0021-9738, 1558-8238
Online Access:Get full text
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Summary:Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppressor, and its deregulation frequently promotes tumorigenesis. In this issue of the JCI, Perego et al. expand that role by showing that Parkin expression stimulated an interferon (IFN) response to modulate CD8+ T cell activity. These findings suggest that, in addition to directly inhibiting tumor progression, Parkin enhances antitumor immune responses, highlighting it as a promising therapeutic target for cancer treatment.
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ISSN:1558-8238
0021-9738
1558-8238
DOI:10.1172/JCI185838