Surgical parameters influence paediatric knee kinematics and cartilage stresses in anterior cruciate ligament reconstruction: Navigating subject‐specific variability using neuromusculoskeletal‐finite element modelling analysis

Purpose Anterior cruciate ligament (ACL) rupture is increasingly common in paediatric and adolescent populations, typically requiring surgical ACL reconstruction (ACLR) to restore knee stability. However, ACLR substantially alters knee biomechanics (e.g., motion and tissue mechanics) placing the pat...

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Veröffentlicht in:Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA Jg. 33; H. 3; S. 817 - 827
Hauptverfasser: Dastgerdi, Ayda Karimi, Esrafilian, Amir, Carty, Christopher P., Nasseri, Azadeh, Barzan, Martina, Korhonen, Rami K., Astori, Ivan, Hall, Wayne, Saxby, David John
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Germany John Wiley and Sons Inc 01.03.2025
Schlagworte:
Adolescent
Anterior Cruciate Ligament Injuries - physiopathology
Anterior Cruciate Ligament Injuries - surgery
Anterior Cruciate Ligament Reconstruction - methods
Biomechanical Phenomena
biomechanics
cartilage
Cartilage, Articular - physiology
Cartilage, Articular - physiopathology
Child
computational modelling
Female
Finite Element Analysis
gait
Humans
in silico
Knee
Knee Joint - physiology
Knee Joint - physiopathology
Knee Joint - surgery
Male
precision medicine
Stress, Mechanical
surgical planning
knee
gait
cartilage
computational modelling
precision medicine
surgical planning
biomechanics
in silico
ISSN:0942-2056, 1433-7347, 1433-7347
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Zusammenfassung:Purpose Anterior cruciate ligament (ACL) rupture is increasingly common in paediatric and adolescent populations, typically requiring surgical ACL reconstruction (ACLR) to restore knee stability. However, ACLR substantially alters knee biomechanics (e.g., motion and tissue mechanics) placing the patient at elevated risk of early‐onset knee osteoarthritis. Methods This study employed a linked neuromusculoskeletal (NMSK)‐finite element (FE) model to determine effects of four critical ACLR surgical parameters (graft type, size, location and pre‐tension) on tibial articular cartilage stresses in three paediatric knees of different sizes during walking. Optimal surgical combinations were defined by minimal kinematic and tibial cartilage stress deviations in comparison to a corresponding intact healthy knee, with substantial deviations defined by normalized root mean square error (nRMSE) > 10%. Results Results showed unique trends of principal stress deviations across knee sizes with small knee showing least deviation from intact knee, followed by large‐ and medium‐sized knees. The nRMSE values for cartilage stresses displayed notable variability across different knees. Surgical combination yielding the highest nRMSE in comparison to the one with lowest nRMSE resulted in an increase of maximum principal stress on the medial tibial cartilage by 18.0%, 6.0% and 1.2% for small, medium and large knees, respectively. Similarly, there was an increase of maximum principal stress on lateral tibial cartilage by 11.2%, 4.1% and 12.7% for small, medium and large knees, respectively. Knee phenotype and NMSK factors contributed to deviations in knee kinematics and tibial cartilage stresses. Although optimal surgical configurations were found for each knee size, no generalizable trends emerged emphasizing the subject‐specific nature of the knee and neuromuscular system. Conclusion Study findings underscore subject‐specific complexities in ACLR biomechanics, necessitating personalized surgical planning for effective restoration of native motion and tissue mechanics. Future research should expand investigations to include a broader spectrum of subject‐specific factors to advance personalized surgical planning. Level of Evidence Level III.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0942-2056
1433-7347
1433-7347
DOI:10.1002/ksa.12413