Radical Brook Rearrangements: Concept and Recent Developments

The Brook rearrangement has already become established as one of the most important molecular rearrangements in synthetic chemistry and has been applied in the generation of complexes, drug discovery, material science, and natural products synthesis. Compared to the widely known ionic mechanism, the...

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 61; no. 37; pp. e202205671 - n/a
Main Authors: Zhang, Ying, Chen, Jun‐Jie, Huang, Huan‐Ming
Format: Journal Article
Language:English
Published: Weinheim Wiley Subscription Services, Inc 12.09.2022
Edition:International ed. in English
Subjects:
Brook Rearrangement
Chemical reactions
Cross coupling
Cross-Coupling Reactions
Natural products
Photoredox Chemistry
Radicals
Transition-Metal Catalysis
ISSN:1433-7851, 1521-3773, 1521-3773
Online Access:Get full text
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Summary:The Brook rearrangement has already become established as one of the most important molecular rearrangements in synthetic chemistry and has been applied in the generation of complexes, drug discovery, material science, and natural products synthesis. Compared to the widely known ionic mechanism, the radical Brook rearrangement is less explored because of the difficulty in generating alkoxyl radical species. This Minireview summarizes the early developments and general concept of the radical Brook rearrangement and highlights recent advances in photocatalytic reactions and transition‐metal‐catalyzed cross‐coupling reactions involving radical Brook rearrangements. We hope this survey will inspire further developments in this emerging area. The radical Brook rearrangement is a unique molecular arrangement, but it is not highly explored in synthetic chemistry. This Minireview summarizes the early developments and general concept of radical Brook rearrangements and highlights the recent advances in photocatalytic reactions and transition‐metal catalyzed cross‐coupling reactions involving radical Brook rearrangements.
Bibliography:These authors contributed equally to this work.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.202205671