Robust Optimal Design for the Estimation of Hyperparameters in Population Pharmacokinetics

The expectation of the determinant of the inverse of the population Fisher information matrix is proposed as a criterion to evaluate and optimize designs for the estimation of population pharmacokinetic (PK) parameters. Given a PK model, a measurement error model, a parametric distribution of the pa...

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Vydané v:	Journal of pharmacokinetics and biopharmaceutics Ročník 26; číslo 6; s. 689 - 716
Hlavní autori:	Tod, Michel, Mentré, France, Merlé, Yann, Mallet, Alain
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York, NY Plenum 01.12.1998 Springer Nature B.V
Predmet:	Biological and medical sciences General pharmacology Humans Medical sciences Models, Biological Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Population Surveillance Studies Human Optimal sampling Compartmental model Methodology Simulation Experimental design Estimation Population Kinetic parameter Pharmacokinetics Optimization Sampling frequency
ISSN:	0090-466X, 1567-567X, 1573-8744
On-line prístup:	Získať plný text
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