Metabolic syndrome and the risk of colorectal cancer: a systematic review and meta-analysis

Purpose Observational studies have reported an association between metabolic syndrome (MetS) and colorectal cancer risk with inconsistent risk estimates. We conducted this meta-analysis to evaluate the risk of colorectal cancer in individuals with MetS. Methods PubMed, Embase, and Web of Science wer...

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Veröffentlicht in:International journal of colorectal disease Jg. 36; H. 10; S. 2215 - 2225
Hauptverfasser: Shen, Xiaoding, Wang, Yong, Zhao, Rui, Wan, Qianyi, Wu, Yutao, Zhao, Lihao, Wu, Xiaoting
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2021
Springer
Springer Nature B.V
Schlagworte:
Body mass index
Cancer
Colorectal cancer
Colorectal carcinoma
Gastroenterology
Hepatology
Hyperglycemia
Insulin resistance
Internal Medicine
Medicine
Medicine & Public Health
Meta-analysis
Metabolic syndrome
Oncology, Experimental
Original Article
Proctology
Risk factors
Surgery
Type 2 diabetes
Risk
Metabolic syndrome
Colorectal cancer
Meta-analysis
ISSN:0179-1958, 1432-1262, 1432-1262
Online-Zugang:Volltext
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Zusammenfassung:Purpose Observational studies have reported an association between metabolic syndrome (MetS) and colorectal cancer risk with inconsistent risk estimates. We conducted this meta-analysis to evaluate the risk of colorectal cancer in individuals with MetS. Methods PubMed, Embase, and Web of Science were searched for related studies from database inception to 21 January 2021. Risk estimates for colorectal cancer were extracted from individual articles and pooled using a fixed-effect or random-effect model according to the heterogeneity. Results MetS was significantly associated with a higher risk of colorectal cancer in both sexes (relative risk [RR] 1.36, 95% confidence interval [CI] 1.26–1.47, P  < 0.001), men (RR 1.33, 95% CI 1.21–1.47, P  < 0.001), and women (RR 1.34, 95% CI 1.19–1.52, P  < 0.001). The risk of colorectal cancer seemed to increase as the number of MetS components rose. Moreover, the high body mass index (BMI)/waist circumference (WC) and hyperglycemia were all significantly associated with a higher risk of colorectal cancer (RR 1.28 [1.20–1.37] and 1.31 [1.14–1.50] in both sexes, RR 1.31 [1.19–1.45] and 1.23 [1.03–1.46] in men, and RR 1.22 [1.02–1.46] and 1.63 [1.16–2.28] in women, respectively). Conclusions MetS was significantly associated with a higher risk of colorectal cancer. The high BMI/WC or hyperglycemia might largely account for this association. Further analysis suggested that, as the number of MetS components increased, the risk of colorectal cancer rose.
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ISSN:0179-1958
1432-1262
1432-1262
DOI:10.1007/s00384-021-03974-y