Ubiquitin-like modification dependent proteasomal degradation and disease therapy

Many proteins have been identified subject to ubiquitin (Ub)-independent proteasome degradation (UbIPD), a process mediated by Ub-like (UBL) proteins.UBL-conjugates can be processed by 19S proteasomes by mechanisms different from Ub-conjugates and by proteasome activator 28γ, which was previously th...

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Veröffentlicht in:	Trends in molecular medicine Jg. 30; H. 11; S. 1061 - 1075
Hauptverfasser:	Wang, Tiantian, Jiang, Jie, Zhang, Xue, Ke, Xisong, Qu, Yi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.11.2024
Schlagworte:	Animals Humans muscle wasting diseases neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism proteasomal degradation Proteasome Endopeptidase Complex - metabolism proteasome regulators Protein Processing, Post-Translational Proteolysis - drug effects ubiquitin-like modification ubiquitin-like proteasome system Ubiquitination - drug effects Ubiquitins - metabolism neurodegenerative diseases proteasome regulators ubiquitin-like modification proteasomal degradation ubiquitin-like proteasome system muscle wasting diseases
ISSN:	1471-4914, 1471-499X, 1471-499X
Online-Zugang:	Volltext
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