Clinical advances of siRNA therapeutics

Small interfering RNA (siRNA) enables efficient target gene silencing by employing a RNA interference (RNAi) mechanism, which can compromise gene expression and regulate gene activity by cleaving mRNA or repressing its translation. Twenty years after the discovery of RNAi in 1998, ONPATTRO™ (patisir...

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Bibliographic Details

Published in:	The journal of gene medicine Vol. 21; no. 7; pp. e3097 - n/a
Main Authors:	Hu, Bo, Weng, Yuhua, Xia, Xin‐Hua, Liang, Xing‐jie, Huang, Yuanyu
Format:	Journal Article
Language:	English
Published:	England Wiley Periodicals Inc 01.07.2019
Subjects:	Gene expression Gene silencing Gene therapy RNA interference RNA-mediated interference siRNA siRNA clinical study siRNA delivery gene silencing siRNA delivery siRNA clinical study siRNA RNA interference
ISSN:	1099-498X, 1521-2254, 1521-2254
Online Access:	Get full text
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