The Chang Gung Research Database—A multi‐institutional electronic medical records database for real‐world epidemiological studies in Taiwan

Purpose The Chang Gung Research Database (CGRD), the largest multi‐institutional electronic medical records (EMR) collection in Taiwan, provides good access for researchers to efficiently use the standardized patient‐level data. This study evaluates the capacity and representativeness of the CGRD to...

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Bibliographic Details
Published in:Pharmacoepidemiology and drug safety Vol. 28; no. 5; pp. 593 - 600
Main Authors: Shao, Shih‐Chieh, Chan, Yuk‐Ying, Kao Yang, Yea‐Huei, Lin, Swu‐Jane, Hung, Ming‐Jui, Chien, Rong‐Nan, Lai, Chi‐Chun, Lai, Edward Chia‐Cheng
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01.05.2019
Subjects:
Chang Gung Research Database
Data Management
Databases, Factual - statistics & numerical data
Databases, Factual - trends
electronic health record
Electronic health records
Electronic Health Records - standards
Electronic Health Records - statistics & numerical data
electronic medical record
Electronic medical records
Epidemiologic Studies
Epidemiology
Geriatrics
Humans
International Classification of Diseases
Medical records
National Health Programs - statistics & numerical data
National Health Programs - trends
Patients
pharmacoepidemiology
real‐world evidence
Researchers
Taiwan - epidemiology
Taiwan
electronic medical record
real-world evidence
electronic health record
Chang Gung Research Database
pharmacoepidemiology
ISSN:1053-8569, 1099-1557, 1099-1557
Online Access:Get full text
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Summary:Purpose The Chang Gung Research Database (CGRD), the largest multi‐institutional electronic medical records (EMR) collection in Taiwan, provides good access for researchers to efficiently use the standardized patient‐level data. This study evaluates the capacity and representativeness of the CGRD to promote secondary use of EMR data for clinical research with more accurate estimates. Methods The National Health Insurance Research Database (NHIRD) which covers over 99.9% of the Taiwanese population served as the comparator in this study. We compare the data components of the CGRD with the NHIRD, including records for health care facilities, patients, diagnoses, drugs, and procedures. Using the chi‐square test, we compared the distributions of age categories and sex of patients, and the rates of their health conditions between NHIRD and CGRD based on the year 2015. Results The CGRD contains more clinical information such as pathological and laboratory results than the NHIRD. The CGRD includes 6.1% of outpatients and 10.2% of hospitalized patients from the NHIRD. We found the CGRD includes more elderly outpatients (23.5% vs 12.5%) and pediatric inpatients (19.7% vs 14.4%) compared with the NHIRD. We found patients' sex distributions were similar between CGRD and NHIRD, but coverage rates of severe conditions, such as cancer, were higher than other health conditions in CGRD. Conclusions The CGRD could serve as the basis for accurate estimates in medical studies. However, researchers should pay special attention to selection biases since patients' characteristics from CGRD differ from those of the national database.
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ISSN:1053-8569
1099-1557
1099-1557
DOI:10.1002/pds.4713