Potential for pharmacokinetic interactions between Schisandra sphenanthera and bosutinib, but not imatinib: in vitro metabolism study combined with a physiologically‐based pharmacokinetic modelling approach

Aims This study aimed to investigate the potential interaction between Schisandra sphenanthera, imatinib and bosutinib combining in vitro and in silico methods. Methods In vitro metabolism of imatinib and bosutinib using recombinant enzymes and human liver microsomes were investigated in the presenc...

Celý popis

Podrobná bibliografia

Vydané v:	British journal of clinical pharmacology Ročník 86; číslo 10; s. 2080 - 2094
Hlavní autori:	Adiwidjaja, Jeffry, Boddy, Alan V., McLachlan, Andrew J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England John Wiley and Sons Inc 01.10.2020
Predmet:	drug metabolism herb–drug interactions modelling and simulation Original physiologically‐based pharmacokinetic (PBPK) physiologically-based pharmacokinetic (PBPK) modelling and simulation herb-drug interactions drug metabolism
ISSN:	0306-5251, 1365-2125, 1365-2125
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!