The molecular mechanism and functional diversity of UPR signaling sensor IRE1

The endoplasmic reticulum is primarily responsible for protein folding and maturation. However, the organelle is subject to varied stress conditions from time to time, which lead to the activation of a signaling program known as the Unfolded Protein Response (UPR) pathway. This pathway, upon sensing...

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Vydáno v:	Life sciences (1973) Ročník 265; s. 118740
Hlavní autoři:	Bashir, Samirul, Banday, Mariam, Qadri, Ozaira, Bashir, Arif, Hilal, Nazia, Nida-i-Fatima, Rader, Stephen, Fazili, Khalid Majid
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Inc 15.01.2021 Elsevier BV
Témata:	Animals Apoptosis Cell Nucleus - metabolism Cytoplasm Divergent cell fates DNA-Binding Proteins - metabolism Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress Endoribonucleases - metabolism Enzymatic activity Enzymes ER-stress Folding functional diversity Homeostasis Humans Inositol Inositol-requiring enzyme 1(IRE1) Kinases Membrane proteins Pleiotropy Protein Folding Protein-Serine-Threonine Kinases - metabolism Proteins Regulated IRE1 Dependent Decay (RIDD) Ribonuclease ribonucleases Signal Transduction Signaling Splicing Substrate Specificity Substrates Transcription Factors - metabolism Unfolded Protein Response Unfolded Protein Response (UPR) X-Box Binding Protein 1 - metabolism X-box protein 1 (Xbp1) Yeast yeasts Unfolded Protein Response (UPR) X-box protein 1 (Xbp1) Divergent cell fates ER-stress Inositol-requiring enzyme 1(IRE1) Regulated IRE1 Dependent Decay (RIDD)
ISSN:	0024-3205, 1879-0631, 1879-0631
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