Establishment of induced pluripotent stem cell lines derived from Parkinson’s disease Mexican patients: A sporadic (UNAMi002-A) and a familial (UNAMi003-A) case carrying a mutation in PINK1

Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in a prominent reduction of striatal dopamine levels leading to motor alterations. The mechanisms underlying neurodegeneration in PD remain unknown. Here, we...

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Veröffentlicht in:Stem cell research Jg. 76; S. 103337
Hauptverfasser: Flores-Ponce, Xóchitl, López-Ornelas, Adolfo, Escobedo-Avila, Itzel, Rodríguez-Violante, Mayela, Dávila-Ortiz de Montellano, David, Cervantes-Arriaga, Amín, Monroy-Jaramillo, Nancy, Campos-Romo, Aurelio, Velasco, Iván
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier B.V 01.04.2024
Elsevier
Schlagworte:
Dopamine - metabolism
Dopaminergic Neurons - metabolism
Humans
Induced Pluripotent Stem Cells - metabolism
Mutation - genetics
Parkinson Disease - genetics
Parkinson Disease - metabolism
Protein Kinases - genetics
ISSN:1873-5061, 1876-7753, 1876-7753
Online-Zugang:Volltext
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Zusammenfassung:Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in a prominent reduction of striatal dopamine levels leading to motor alterations. The mechanisms underlying neurodegeneration in PD remain unknown. Here, we generated an induced pluripotent stem cell line from dermal fibroblasts of a Mexican patient diagnosed with sporadic PD (UNAMi002-A) and another cell line from dermal fibroblasts of a patient carrying the point mutation c.1423delC in PINK1 (UNAMi003-A). These patient-derived iPS cell lines offer the possibility of modeling PD and understanding the mechanisms that contribute to dopamine neuron loss.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2024.103337