Generation of a human induced pluripotent stem cell line (UNAMi001-A) from a Mexican patient with sporadic Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disease caused by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in motor alterations. The exact mechanisms underlying the dopaminergic neurodegeneration in PD are still unknown. Here, we generated a human...

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Veröffentlicht in:Stem cell research Jg. 65; S. 102972
Hauptverfasser: Flores-Ponce, Xóchitl, López-Ornelas, Adolfo, Escobedo-Avila, Itzel, Rodríguez-Violante, Mayela, Dávila-Ortiz de Montellano, David, Cervantes-Arriaga, Amín, Monroy-Jaramillo, Nancy, Velasco, Iván
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier B.V 01.12.2022
Elsevier
Schlagworte:
Humans
Induced Pluripotent Stem Cells
Neurodegenerative Diseases
Parkinson Disease
ISSN:1873-5061, 1876-7753, 1876-7753
Online-Zugang:Volltext
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Zusammenfassung:Parkinson’s disease (PD) is a neurodegenerative disease caused by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in motor alterations. The exact mechanisms underlying the dopaminergic neurodegeneration in PD are still unknown. Here, we generated a human induced pluripotent stem cell (iPSC) line from dermal fibroblasts of a Mexican patient diagnosed with sporadic PD. The generated iPS cell line (UNAMi001-A) express pluripotency markers, maintain a normal karyotype and display the ability to differentiate into all three germ layers. This is the first iPSC line from a Mexican patient and will be useful for PD modeling.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2022.102972