Generation of a human induced pluripotent stem cell line (UNAMi001-A) from a Mexican patient with sporadic Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disease caused by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in motor alterations. The exact mechanisms underlying the dopaminergic neurodegeneration in PD are still unknown. Here, we generated a human...

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Vydané v:Stem cell research Ročník 65; s. 102972
Hlavní autori: Flores-Ponce, Xóchitl, López-Ornelas, Adolfo, Escobedo-Avila, Itzel, Rodríguez-Violante, Mayela, Dávila-Ortiz de Montellano, David, Cervantes-Arriaga, Amín, Monroy-Jaramillo, Nancy, Velasco, Iván
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier B.V 01.12.2022
Elsevier
Predmet:
Humans
Induced Pluripotent Stem Cells
Neurodegenerative Diseases
Parkinson Disease
ISSN:1873-5061, 1876-7753, 1876-7753
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Shrnutí:Parkinson’s disease (PD) is a neurodegenerative disease caused by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in motor alterations. The exact mechanisms underlying the dopaminergic neurodegeneration in PD are still unknown. Here, we generated a human induced pluripotent stem cell (iPSC) line from dermal fibroblasts of a Mexican patient diagnosed with sporadic PD. The generated iPS cell line (UNAMi001-A) express pluripotency markers, maintain a normal karyotype and display the ability to differentiate into all three germ layers. This is the first iPSC line from a Mexican patient and will be useful for PD modeling.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2022.102972