A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion

Abstract Aims Apolipoprotein B (APOB)-containing very LDL (VLDL) production, secretion, and clearance by hepatocytes is a central determinant of hepatic and circulating lipid levels. Impairment of any of the aforementioned processes is associated with the development of multiple diseases. Despite th...

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Bibliographic Details
Published in:	Cardiovascular research Vol. 120; no. 11; pp. 1253 - 1264
Main Authors:	Meurs, Amber, Ndoj, Klevis, van den Berg, Marlene, Marinković, Goran, Tantucci, Matteo, Veenendaal, Tineke, Kuivenhoven, Jan Albert, Klumperman, Judith, Zelcer, Noam
Format:	Journal Article
Language:	English
Published:	UK Oxford University Press 21.09.2024
Subjects:	Apolipoprotein B-100 - genetics Apolipoprotein B-100 - metabolism CRISPR-Cas Systems Endoplasmic Reticulum - metabolism Gene Editing Golgi Apparatus - metabolism Hep G2 Cells Hepatocytes - metabolism Humans Lipoproteins, VLDL - metabolism Receptors, LDL - genetics Receptors, LDL - metabolism Time Factors ERAD Hepatocytes HRD1 VLDL SYVN1 APOB MASLD Lipoprotein metabolism
ISSN:	0008-6363, 1755-3245, 1755-3245
Online Access:	Get full text
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