Cryo-EM structures capture the transport cycle of the P4-ATPase flippase

In eukaryotic membranes, type IV P-type adenosine triphosphatases (P4-ATPases) mediate the translocation of phospholipids from the outer to the inner leaflet and maintain lipid asymmetry, which is critical for membrane trafficking and signaling pathways. Here, we report the cryo-electron microscopy...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 365; H. 6458; S. 1149
Hauptverfasser:	Hiraizumi, Masahiro, Yamashita, Keitaro, Nishizawa, Tomohiro, Nureki, Osamu
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 13.09.2019
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphate - chemistry Amino Acid Sequence Binding Sites Cryoelectron Microscopy HEK293 Cells Humans Membrane Proteins - chemistry Models, Molecular Phosphatidylserines Phospholipid Transfer Proteins - chemistry Phospholipids - metabolism Phosphorylation Protein Binding Protein Interaction Domains and Motifs Protein Structure, Quaternary Sequence Alignment
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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