Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools

DNA sequencing identifies common and rare genetic variants for association studies, but studies typically focus on variants in nuclear DNA and ignore the mitochondrial genome. In fact, analyzing variants in mitochondrial DNA (mtDNA) sequences presents special problems, which we resolve here with a g...

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Bibliographic Details
Published in:	PLoS genetics Vol. 11; no. 7; p. e1005306
Main Authors:	Ding, Jun, Sidore, Carlo, Butler, Thomas J., Wing, Mary Kate, Qian, Yong, Meirelles, Osorio, Busonero, Fabio, Tsoi, Lam C., Maschio, Andrea, Angius, Andrea, Kang, Hyun Min, Nagaraja, Ramaiah, Cucca, Francesco, Abecasis, Gonçalo R., Schlessinger, David
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.07.2015 Public Library of Science (PLoS)
Subjects:	Age Aging Algorithms Base Sequence Body Fat Distribution Body Mass Index Deoxyribonucleic acid DNA DNA Copy Number Variations - genetics DNA, Mitochondrial - genetics Female Gene Dosage - genetics Genes Genomes High-Throughput Nucleotide Sequencing Humans Lymphocytes Lymphocytes - cytology Male Metabolism Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Obesity - genetics Population Sequence Analysis, DNA Sex Factors Studies Waist Circumference - genetics Waist-Hip Ratio
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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