Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity

Isatin, 1H-indole-2,3-dione, is a heterocyclic compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule, a precursor for a large number of pharmacologically active compounds. Isatin and its derivatives have aroused great attention in recent years due to the...

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Vydáno v:Pharmacological reports Ročník 65; číslo 2; s. 313 - 335
Hlavní autoři: Pakravan, Parvaneh, Kashanian, Soheila, Khodaei, Mohammad M., Harding, Frances J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Elsevier B.V 01.03.2013
Springer International Publishing
Témata:
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
anticancer
anticonvulsant
Antidepressive Agents - chemistry
Antidepressive Agents - pharmacology
antimicrobial
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
antioxidant
derivatives
DNA and HSA binding
Drug Design
Drug Safety and Pharmacovigilance
Humans
isatin
Isatin - analogs & derivatives
Isatin - chemistry
Isatin - pharmacology
Pesticides - chemistry
Pesticides - pharmacology
Pharmacotherapy
Pharmacy
Review
Structure-Activity Relationship
DNA and HSA binding
derivatives
antimicrobial
antioxidant
anticonvulsant
isatin
anticancer
ISSN:1734-1140, 2299-5684, 2299-5684
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Shrnutí:Isatin, 1H-indole-2,3-dione, is a heterocyclic compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule, a precursor for a large number of pharmacologically active compounds. Isatin and its derivatives have aroused great attention in recent years due to their wide variety of biological activities, relevant to application as insecticides and fungicides and in a broad range of drug therapies, including anticancer drugs, antibiotics and antidepressants. The purpose of this review is to provide an overview of the pharmacological activities of isatin and its synthetic and natural derivatives. Molecular modifications to tailor the properties of isatin and its derivatives are also discussed.
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ISSN:1734-1140
2299-5684
2299-5684
DOI:10.1016/S1734-1140(13)71007-7