Optimizing ex vivo penetration tests via quantitative confocal Raman spectroscopy: Impact of incubation time, skin hydration, surfactant treatment and UVA irradiation on caffeine distribution
[Display omitted] Ex vivo penetration tests are important tools in cosmetic and pharmaceutical research. However, variability of experimental setups is challenging when reviewing literature. Different skin models, pre-treatments and experimental parameters render comparison difficult. Thus, our aim...
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| Published in: | International journal of pharmaceutics Vol. 667; no. Pt B; p. 124932 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
25.12.2024
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| ISSN: | 0378-5173, 1873-3476, 1873-3476 |
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| Abstract | [Display omitted]
Ex vivo penetration tests are important tools in cosmetic and pharmaceutical research. However, variability of experimental setups is challenging when reviewing literature. Different skin models, pre-treatments and experimental parameters render comparison difficult. Thus, our aim was to conduct ex vivo penetration tests using caffeine in different setups with varying incubation conditions (ambient vs. Franz cells, infinite vs. finite dose). Additionally, the impact of skin pre-treatment with different aggressors (surfactants, UVA irradiation) should be considered. Possible synergistic barrier damage of surfactants and UVA irradiation should be explored. Analysis was conducted using quantitative confocal Raman spectroscopy. Results showed that incubation time and extensive hydration (20 h in Franz cells) had the greatest impact on penetration behavior. Additional irradiation after pre-treatment with oil-in-water nanoemulsions showed no strong impact on caffeine penetration in general, irrespective of surfactant type. However, in case of sodium lauryl ether sulfate, a trend towards enhanced values was observed due to irradiation (1.3-fold). This suggests cumulative skin barrier damage of irritant surfactants and UVA irradiation, potentially due to stratum corneum alterations. Further studies using different irradiation regimens are planned to confirm this hypothesis. |
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| AbstractList | [Display omitted]
Ex vivo penetration tests are important tools in cosmetic and pharmaceutical research. However, variability of experimental setups is challenging when reviewing literature. Different skin models, pre-treatments and experimental parameters render comparison difficult. Thus, our aim was to conduct ex vivo penetration tests using caffeine in different setups with varying incubation conditions (ambient vs. Franz cells, infinite vs. finite dose). Additionally, the impact of skin pre-treatment with different aggressors (surfactants, UVA irradiation) should be considered. Possible synergistic barrier damage of surfactants and UVA irradiation should be explored. Analysis was conducted using quantitative confocal Raman spectroscopy. Results showed that incubation time and extensive hydration (20 h in Franz cells) had the greatest impact on penetration behavior. Additional irradiation after pre-treatment with oil-in-water nanoemulsions showed no strong impact on caffeine penetration in general, irrespective of surfactant type. However, in case of sodium lauryl ether sulfate, a trend towards enhanced values was observed due to irradiation (1.3-fold). This suggests cumulative skin barrier damage of irritant surfactants and UVA irradiation, potentially due to stratum corneum alterations. Further studies using different irradiation regimens are planned to confirm this hypothesis. Ex vivo penetration tests are important tools in cosmetic and pharmaceutical research. However, variability of experimental setups is challenging when reviewing literature. Different skin models, pre-treatments and experimental parameters render comparison difficult. Thus, our aim was to conduct ex vivo penetration tests using caffeine in different setups with varying incubation conditions (ambient vs. Franz cells, infinite vs. finite dose). Additionally, the impact of skin pre-treatment with different aggressors (surfactants, UVA irradiation) should be considered. Possible synergistic barrier damage of surfactants and UVA irradiation should be explored. Analysis was conducted using quantitative confocal Raman spectroscopy. Results showed that incubation time and extensive hydration (20 h in Franz cells) had the greatest impact on penetration behavior. Additional irradiation after pre-treatment with oil-in-water nanoemulsions showed no strong impact on caffeine penetration in general, irrespective of surfactant type. However, in case of sodium lauryl ether sulfate, a trend towards enhanced values was observed due to irradiation (1.3-fold). This suggests cumulative skin barrier damage of irritant surfactants and UVA irradiation, potentially due to stratum corneum alterations. Further studies using different irradiation regimens are planned to confirm this hypothesis.Ex vivo penetration tests are important tools in cosmetic and pharmaceutical research. However, variability of experimental setups is challenging when reviewing literature. Different skin models, pre-treatments and experimental parameters render comparison difficult. Thus, our aim was to conduct ex vivo penetration tests using caffeine in different setups with varying incubation conditions (ambient vs. Franz cells, infinite vs. finite dose). Additionally, the impact of skin pre-treatment with different aggressors (surfactants, UVA irradiation) should be considered. Possible synergistic barrier damage of surfactants and UVA irradiation should be explored. Analysis was conducted using quantitative confocal Raman spectroscopy. Results showed that incubation time and extensive hydration (20 h in Franz cells) had the greatest impact on penetration behavior. Additional irradiation after pre-treatment with oil-in-water nanoemulsions showed no strong impact on caffeine penetration in general, irrespective of surfactant type. However, in case of sodium lauryl ether sulfate, a trend towards enhanced values was observed due to irradiation (1.3-fold). This suggests cumulative skin barrier damage of irritant surfactants and UVA irradiation, potentially due to stratum corneum alterations. Further studies using different irradiation regimens are planned to confirm this hypothesis. Ex vivo penetration tests are important tools in cosmetic and pharmaceutical research. However, variability of experimental setups is challenging when reviewing literature. Different skin models, pre-treatments and experimental parameters render comparison difficult. Thus, our aim was to conduct ex vivo penetration tests using caffeine in different setups with varying incubation conditions (ambient vs. Franz cells, infinite vs. finite dose). Additionally, the impact of skin pre-treatment with different aggressors (surfactants, UVA irradiation) should be considered. Possible synergistic barrier damage of surfactants and UVA irradiation should be explored. Analysis was conducted using quantitative confocal Raman spectroscopy. Results showed that incubation time and extensive hydration (20 h in Franz cells) had the greatest impact on penetration behavior. Additional irradiation after pre-treatment with oil-in-water nanoemulsions showed no strong impact on caffeine penetration in general, irrespective of surfactant type. However, in case of sodium lauryl ether sulfate, a trend towards enhanced values was observed due to irradiation (1.3-fold). This suggests cumulative skin barrier damage of irritant surfactants and UVA irradiation, potentially due to stratum corneum alterations. Further studies using different irradiation regimens are planned to confirm this hypothesis. |
| ArticleNumber | 124932 |
| Author | Steiner, Katja Klang, Victoria Hübel, Pia Srndic, Azra |
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| Cites_doi | 10.1016/j.colsurfa.2015.01.019 10.1016/j.addr.2015.04.002 10.1111/ics.12139 10.1111/j.1600-0846.2006.00179.x 10.3390/membranes12030251 10.1073/pnas.1206851109 10.1016/j.cofs.2015.07.008 10.1016/j.ijpharm.2018.08.007 10.1111/srt.12709 10.1111/j.1468-3083.2009.03349.x 10.1016/j.ijpharm.2019.05.078 10.1111/j.1396-0296.2004.04S1002.x 10.3390/pharmaceutics12121235 10.1016/j.ijpharm.2020.119209 10.1111/srt.12968 10.1007/s00253-022-12302-5 10.1007/s00403-018-1854-4 10.1159/000475472 10.1007/978-3-030-16573-4_6 10.3390/molecules27062010 10.1046/j.1523-1747.2001.01258.x 10.1016/j.ijpharm.2014.08.058 10.1016/j.ijpharm.2021.121055 10.3390/pharmaceutics13040436 10.1007/s11095-022-03245-7 10.1111/exd.14645 10.1016/j.ejpb.2012.11.017 10.3390/chemosensors9090262 10.3390/pharmaceutics12020152 10.1111/ics.12042 10.1159/000247822 10.1111/1523-1747.ep12328031 10.1111/1523-1747.ep12471711 10.1034/j.1600-0536.2003.480105.x 10.1002/ejlt.201400219 10.1016/j.ijpharm.2024.123903 10.1016/j.jconrel.2016.06.017 10.1016/j.xphs.2019.06.030 10.1016/j.ijpharm.2011.07.025 10.1016/j.ejpb.2021.04.027 10.1016/j.mattod.2017.11.002 |
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| Keywords | UVA SLES UV CRS quantitative CRS Surfactant SC Porcine ear skin Penetration PC PE NE Confocal Raman spectroscopy LPC PS80 Caffeine HLB MCT |
| Language | English |
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Ex vivo penetration tests are important tools in cosmetic and pharmaceutical research. However, variability of experimental setups is... Ex vivo penetration tests are important tools in cosmetic and pharmaceutical research. However, variability of experimental setups is challenging when... |
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| SubjectTerms | Animals Caffeine Caffeine - pharmacokinetics Confocal Raman spectroscopy Humans Penetration Porcine ear skin quantitative CRS Skin - metabolism Skin - radiation effects Skin Absorption Sodium Dodecyl Sulfate - analogs & derivatives Sodium Dodecyl Sulfate - chemistry Spectrum Analysis, Raman - methods Surface-Active Agents - chemistry Surfactant Time Factors Ultraviolet Rays UVA Water - chemistry |
| Title | Optimizing ex vivo penetration tests via quantitative confocal Raman spectroscopy: Impact of incubation time, skin hydration, surfactant treatment and UVA irradiation on caffeine distribution |
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