Implementation of a Rapid Phenotypic Susceptibility Platform for Gram-Negative Bloodstream Infections With Paired Antimicrobial Stewardship Intervention: Is the Juice Worth the Squeeze?

Abstract Background Implementation of the Accelerate PhenoTM Gram-negative platform (RDT) paired with antimicrobial stewardship program (ASP) intervention projects to improve time to institutional-preferred antimicrobial therapy (IPT) for Gram-negative bacilli (GNB) bloodstream infections (BSIs). Ho...

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Published in:Clinical infectious diseases Vol. 73; no. 5; pp. 783 - 792
Main Authors: Robinson, Evan D, Stilwell, Allison M, Attai, April E, Donohue, Lindsay E, Shah, Megan D, Hill, Brandon K, Elliott, Zachary S, Poulter, Melinda, Brewster, Frankie, Cox, Heather L, Mathers, Amy J
Format: Journal Article
Language:English
Published: US Oxford University Press 07.09.2021
Subjects:
Adult
Anti-Bacterial Agents - therapeutic use
Antimicrobial Stewardship
Bacteremia - drug therapy
Blood Culture
Gram-Negative Bacteria
Humans
Sepsis - drug therapy
bloodstream infections
rapid diagnostics
susceptibility testing
antimicrobial stewardship
ISSN:1058-4838, 1537-6591, 1537-6591
Online Access:Get full text
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Summary:Abstract Background Implementation of the Accelerate PhenoTM Gram-negative platform (RDT) paired with antimicrobial stewardship program (ASP) intervention projects to improve time to institutional-preferred antimicrobial therapy (IPT) for Gram-negative bacilli (GNB) bloodstream infections (BSIs). However, few data describe the impact of discrepant RDT results from standard of care (SOC) methods on antimicrobial prescribing. Methods A single-center, pre-/post-intervention study of consecutive, nonduplicate blood cultures for adult inpatients with GNB BSI following combined RDT + ASP intervention was performed. The primary outcome was time to IPT. An a priori definition of IPT was utilized to limit bias and to allow for an assessment of the impact of discrepant RDT results with the SOC reference standard. Results Five hundred fourteen patients (PRE 264; POST 250) were included. Median time to antimicrobial susceptibility testing (AST) results decreased 29.4 hours (P < .001) post-intervention, and median time to IPT was reduced by 21.2 hours (P < .001). Utilization (days of therapy [DOTs]/1000 days present) of broad-spectrum agents decreased (PRE 655.2 vs POST 585.8; P = .043) and narrow-spectrum beta-lactams increased (69.1 vs 141.7; P < .001). Discrepant results occurred in 69/250 (28%) post-intervention episodes, resulting in incorrect ASP recommendations in 10/69 (14%). No differences in clinical outcomes were observed. Conclusions While implementation of a phenotypic RDT + ASP can improve time to IPT, close coordination with Clinical Microbiology and continued ASP follow up are needed to optimize therapy. Although uncommon, the potential for erroneous ASP recommendations to de-escalate to inactive therapy following RDT results warrants further investigation. Implementation of a rapid phenotypic diagnostic test, plus antimicrobial stewardship intervention for Gram-negative bloodstream infections, was associated with significantly faster time to institutional preferred therapy without change in clinical outcomes. Occasional erroneous results contributed to incorrect ASP recommendations.
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ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciab126