Efficacy of a novel dentifrice containing bioactive glass-ceramic for dentinal hypersensitivity: A double-blind randomized controlled trial in Chinese adults

To assess the efficacy and safety of a toothpaste containing 7.5 % HX-BGC in combating dentinal hypersensitivity. A single-center, randomized, double-blind, three-group parallel-controlled design was employed, with Schiff Index and Yeaple Index as measurement indicators. The study evaluated the effe...

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Vydáno v:Journal of dentistry Ročník 144; s. 104898
Hlavní autoři: Li, Jia, Han, Qi, Zhang, Li, Zhang, Jing, Yin, Wei, Zhong, Yisi
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.05.2024
Témata:
Adult
Bioactive glass-ceramic
Ceramics - therapeutic use
China
Dentifrices - therapeutic use
Dentin Desensitizing Agents - therapeutic use
Dentin Sensitivity - drug therapy
Dentinal hypersensitivity
Dentine permeability
Double-Blind Method
East Asian People
Female
Fluorides - therapeutic use
Follow-Up Studies
Glass
Humans
Male
Middle Aged
Novamin
Phosphates - therapeutic use
RCT
Safety
toothpaste
Toothpastes - therapeutic use
Treatment Outcome
Young Adult
China
Dentine permeability
RCT
Novamin
Bioactive glass-ceramic
toothpaste
Dentinal hypersensitivity
ISSN:0300-5712, 1879-176X, 1879-176X
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Shrnutí:To assess the efficacy and safety of a toothpaste containing 7.5 % HX-BGC in combating dentinal hypersensitivity. A single-center, randomized, double-blind, three-group parallel-controlled design was employed, with Schiff Index and Yeaple Index as measurement indicators. The study evaluated the effectiveness of HX-BGC toothpaste, NovaMin toothpaste, and a negative control toothpaste without desensitizing agents. Eligible subjects underwent baseline examination after a 2-week washout period, and those meeting inclusion criteria and not meeting exclusion criteria entered the study. Participants were randomly assigned to use one of the three toothpastes. Follow-up examinations were conducted immediately after a single use and at 2, 4, and 6 weeks. Intra-group and inter-group comparisons were made for Schiff and Yeaple indices. Safety of the experimental toothpastes was assessed through participant feedbacks and oral soft tissue examinations. Subjects in the three groups were balanced in terms of age and gender distribution, with no baseline differences in indicators. Immediately after a single application of toothpaste, Yeaple indices increased, and Schiff indices decreased, with no significant differences among the groups. After 2 weeks of continuous use, Yeaple indices increased in all groups, with significant differences observed between the HX-BGC group and the other two groups. Schiff indices decreased in all groups, with the NovaMin group showing significant differences compared to the negative control group. At weeks 4 and 6, both indices in the HX-BGC group and the NovaMin group were significantly better than those in the negative control group, with the HX-BGC group outperforming the NovaMin group in the Yeaple index. No serious adverse reactions related to the study products were observed or reported by any participants. This clinical trial confirmed the efficacy of HX-BGC in anti-dentinal hypersensitivity and supported the clinical application of the dentifrice containing HX-BGC. Compared to the negative control group, both HX-BGC and NovaMin toothpaste groups demonstrated more significant effects in combating dentinal hypersensitivity. No adverse reactions related to the experimental toothpastes were observed.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
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ISSN:0300-5712
1879-176X
1879-176X
DOI:10.1016/j.jdent.2024.104898