Endothelial Reprogramming Stimulated by Oncostatin M Promotes Inflammation and Tumorigenesis in VHL -Deficient Kidney Tissue

Clear-cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell carcinoma (RCC), and its progression has been linked to chronic inflammation. About 70% of the ccRCC cases are associated with inactivation of the von Hippel-Lindau ( ) tumor-suppressor gene. However, it is still not...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 81; H. 19; S. 5060
Hauptverfasser:	Nguyen-Tran, Hieu-Huy, Nguyen, Thi-Ngoc, Chen, Chen-Yun, Hsu, Tien
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2021
Schlagworte:	Animals Cell Line Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cellular Reprogramming - genetics Disease Models, Animal Disease Susceptibility Endothelial Cells - metabolism Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation Humans Immunohistochemistry Kidney Neoplasms - etiology Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Macrophages - immunology Macrophages - metabolism Mice Mice, Transgenic Mutation Oncostatin M - genetics Oncostatin M - metabolism Phenotype Signal Transduction Tumor Microenvironment - genetics Von Hippel-Lindau Tumor Suppressor Protein - genetics
ISSN:	1538-7445, 1538-7445
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