Short- and long-term mortality and causes of death in HIV/tuberculosis patients in Europe

Mortality of HIV/tuberculosis (TB) patients in Eastern Europe is high. Little is known about their causes of death. This study aimed to assess and compare mortality rates and cause of death in HIV/TB patients across Eastern Europe and Western Europe and Argentina (WEA) in an international cohort stu...

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Vydáno v:The European respiratory journal Ročník 43; číslo 1; s. 166
Hlavní autoři: Podlekareva, Daria N, Panteleev, Alexander M, Grint, Daniel, Post, Frank A, Miro, Jose M, Bruyand, Mathias, Furrer, Hansjakob, Obel, Niels, Girardi, Enrico, Vasilenko, Anna, Losso, Marcelo H, Arenas-Pinto, Alejandro, Caylá, Joan, Rakhmanova, Aza, Zeltina, Indra, Werlinrud, Anne Marie, Lundgren, Jens D, Mocroft, Amanda, Kirk, Ole
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.01.2014
Témata:
Adult
Anti-HIV Agents - therapeutic use
Antitubercular Agents - therapeutic use
Argentina
Cause of Death
Cohort Studies
Coinfection - mortality
Europe
Female
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - mortality
Humans
Male
Multivariate Analysis
Tuberculosis - complications
Tuberculosis - drug therapy
Tuberculosis - mortality
Argentina
Europe
ISSN:1399-3003, 1399-3003
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Shrnutí:Mortality of HIV/tuberculosis (TB) patients in Eastern Europe is high. Little is known about their causes of death. This study aimed to assess and compare mortality rates and cause of death in HIV/TB patients across Eastern Europe and Western Europe and Argentina (WEA) in an international cohort study. Mortality rates and causes of death were analysed by time from TB diagnosis (<3 months, 3-12 months or >12 months) in 1078 consecutive HIV/TB patients. Factors associated with TB-related death were examined in multivariate Poisson regression analysis. 347 patients died during 2625 person-years of follow-up. Mortality in Eastern Europe was three- to ninefold higher than in WEA. TB was the main cause of death in Eastern Europe in 80%, 66% and 61% of patients who died <3 months, 3-12 months or >12 months after TB diagnosis, compared to 50%, 0% and 15% in the same time periods in WEA (p<0.0001). In multivariate analysis, follow-up in WEA (incidence rate ratio (IRR) 0.12, 95% CI 0.04-0.35), standard TB-treatment (IRR 0.45, 95% CI 0.20-0.99) and antiretroviral therapy (IRR 0.32, 95% CI 0.14-0.77) were associated with reduced risk of TB-related death. Persistently higher mortality rates were observed in HIV/TB patients in Eastern Europe, and TB was the dominant cause of death at any time during follow-up. This has important implications for HIV/TB programmes aiming to optimise the management of HIV/TB patients and limit TB-associated mortality in this region.
Bibliografie:ObjectType-Article-1
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ISSN:1399-3003
1399-3003
DOI:10.1183/09031936.00138712