The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity

rs5758550 has been associated with enhanced transcription and suggested to be a useful marker of CYP2D6 activity. As there are limited and inconsistent data regarding the utility of this distant "enhancer" single nucleotide polymorphism (SNP), our goal was to further assess the impact of r...

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Vydané v:	Clinical pharmacology and therapeutics Ročník 111; číslo 3; s. 646
Hlavní autori:	Dinh, Jean C, Boone, Erin C, Staggs, Vincent S, Pearce, Robin E, Wang, Wendy Y, Gaedigk, Roger, Leeder, James Steven, Gaedigk, Andrea
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.03.2022
Predmet:	Adolescent Alleles Atomoxetine Hydrochloride - therapeutic use Child Cytochrome P-450 CYP2D6 - genetics Dextromethorphan - therapeutic use Genotype Haplotypes - genetics Humans Pharmacogenomic Testing - methods Phenotype Polymorphism, Single Nucleotide - genetics
ISSN:	1532-6535, 1532-6535
On-line prístup:	Zistit podrobnosti o prístupe
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