Treatment of Periodontal Disease in Diabetics Reduces Glycated Hemoglobin

Periodontal disease is a common infection‐induced inflammatory disease among individuals suffering from diabetes mellitus. The purpose of this study was to assess the effects of treatment of periodontal disease on the level of metabolic control of diabetes. A total of 113 Native Americans (81 female...

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Vydáno v:Journal of periodontology (1970) Ročník 68; číslo 8; s. 713 - 719
Hlavní autoři: Grossi, Sara G., Skrepcinski, Fred B., DeCaro, Thomas, Robertson, Don C., Ho, Alex W., Dunford, Robert G., Genco, Robert J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.08.1997
Témata:
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Anti-Infective Agents, Local - administration & dosage
Anti-Infective Agents, Local - therapeutic use
Arizona
Blood Glucose - analysis
Chlorhexidine - administration & dosage
Chlorhexidine - therapeutic use
Dental Plaque - microbiology
Dental Scaling
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Doxycycline - administration & dosage
Doxycycline - therapeutic use
Female
Glycated Hemoglobin A - analysis
Humans
Indians, North American
Iodophors - administration & dosage
Iodophors - therapeutic use
Male
Middle Aged
Mouthwashes
non‐insulin dependent/epidemiology
Periodontal Attachment Loss - therapy
Periodontal Diseases - complications
Periodontal Diseases - microbiology
Periodontal Diseases - therapy
Periodontal Pocket - therapy
Periodontitis - therapy
Placebos
Porphyromonas gingivalis
Porphyromonas gingivalis - drug effects
Povidone-Iodine - administration & dosage
Povidone-Iodine - therapeutic use
povidoneiodine/therapeutic use
Subgingival Curettage
Ultrasonic Therapy
ISSN:0022-3492, 1943-3670
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Shrnutí:Periodontal disease is a common infection‐induced inflammatory disease among individuals suffering from diabetes mellitus. The purpose of this study was to assess the effects of treatment of periodontal disease on the level of metabolic control of diabetes. A total of 113 Native Americans (81 females and 32 males) suffering from periodontal disease and non‐insulin dependent diabetes mellitus (NIDDM) were randomized into 5 treatment groups. Periodontal treatment included ultrasonic scaling and curettage combined with one of the following antimicrobial regimens: 1) topical water and systemic doxycycline, 100 mg for 2 weeks; 2) topical 0.12% chlorhexidine (CHX) and systemic doxycycline, 100 mg for 2 weeks; 3) topical povidone‐iodine and systemic doxycycline, 100 mg for 2 weeks; 4) topical 0.12% CHX and placebo; and 5) topical water and placebo (control group). Assessments were performed prior to and at 3 and 6 months after treatment and included probing depth (PD), clinical attachment level (CAL), detection of Porphyromonas gingivalis in subgingival plaque and determination of serum glucose and glycated hemoglobin (HbAlc). After treatment all study groups showed clinical and microbial improvement. The doxycycline‐treated groups showed the greatest reduction in probing depth and subgingival Porphyromonas gingivalis compared to the control group. In addition, all 3 groups receiving systemic doxycycline showed, at 3 months, significant reductions (P ≤ 0.04) in mean HbAlc reaching nearly 10% from the pretreatment value. Effective treatment of periodontal infection and reduction of periodontal inflammation is associated with a reduction in level of glycated hemoglobin. Control of periodontal infections should thus be an important part of the overall management of diabetes mellitus patients. J Periodontol 1997;68:713–719.
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ISSN:0022-3492
1943-3670
DOI:10.1902/jop.1997.68.8.713