Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy

Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress response programs that counteract the inherent toxicity of such aberrant signaling. Although inhibition of oncogenic signaling pathways has been explored extensively, there is...

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Veröffentlicht in:	Cancer discovery Jg. 14; H. 7; S. 1276
Hauptverfasser:	Dias, Matheus Henrique, Friskes, Anoek, Wang, Siying, Fernandes Neto, Joao M, van Gemert, Frank, Mourragui, Soufiane, Papagianni, Chrysa, Kuiken, Hendrik J, Mainardi, Sara, Alvarez-Villanueva, Daniel, Lieftink, Cor, Morris, Ben, Dekker, Anna, van Dijk, Emma, Wilms, Lieke H S, da Silva, Marcelo S, Jansen, Robin A, Mulero-Sánchez, Antonio, Malzer, Elke, Vidal, August, Santos, Cristina, Salazar, Ramón, Wailemann, Rosangela A M, Torres, Thompson E P, De Conti, Giulia, Raaijmakers, Jonne A, Snaebjornsson, Petur, Yuan, Shengxian, Qin, Wenxin, Kovach, John S, Armelin, Hugo A, Te Riele, Hein, van Oudenaarden, Alexander, Jin, Haojie, Beijersbergen, Roderick L, Villanueva, Alberto, Medema, Rene H, Bernards, Rene
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2024
Schlagworte:	Animals Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - metabolism Cell Line, Tumor Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology DNA Replication Drug Resistance, Neoplasm Humans Mice Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Phosphatase 2 - metabolism Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Signal Transduction Xenograft Model Antitumor Assays
ISSN:	2159-8290, 2159-8290
Online-Zugang:	Weitere Angaben
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