Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example

The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the concept: enhanced genetic discoveries,...

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Vydané v:Journal of personalized medicine Ročník 11; číslo 5; s. 358
Hlavní autori: Prins, Bram Peter, Leitsalu, Liis, Pärna, Katri, Fischer, Krista, Metspalu, Andres, Haller, Toomas, Snieder, Harold
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 29.04.2021
MDPI
Predmet:
Algorithms
Biobanks
Consortia
Data compression
Gene loci
Genomes
Genomics
Information sharing
Precision medicine
Review
Y chromosomes
United Kingdom > UK
genomic medicine
return of results
patient communication
biobank
genetic discovery
Estonia
ISSN:2075-4426, 2075-4426
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Shrnutí:The current paradigm of personalized medicine envisages the use of genomic data to provide predictive information on the health course of an individual with the aim of prevention and individualized care. However, substantial efforts are required to realize the concept: enhanced genetic discoveries, translation into intervention strategies, and a systematic implementation in healthcare. Here we review how further genetic discoveries are improving personalized prediction and advance functional insights into the link between genetics and disease. In the second part we give our perspective on the way these advances in genomic research will transform the future of personalized prevention and medicine using Estonia as a primer.
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These authors contributed equally.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11050358