Prevalence of Gastrointestinal and Cardiovascular Risk in Patients with Degenerative Lumbar Spinal Disease

Limited information is available about the proportion of patients with degenerative lumbar spinal disease (DLSD) who have gastrointestinal (GI) and cardiovascular (CV) risk factors. Many DLSD patients are prescribed nonsteroidal anti-inflammatory drugs (NSAIDs) that are known to carry risks to the G...

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Vydáno v:Clinics in orthopedic surgery Ročník 12; číslo 3; s. 343 - 352
Hlavní autoři: Yang, Jae-Ho, Lee, Byoung-Ho, Eum, Kwang-Sik, Suk, Kyoung-Soo, Park, Jin-Oh, Kim, Hak-Sun, Lee, Hwan-Mo, Moon, Seong-Hwan
Médium: Journal Article
Jazyk:angličtina
Vydáno: Korea (South) The Korean Orthopaedic Association 01.09.2020
대한정형외과학회
Témata:
Aged
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Cardiovascular Diseases - chemically induced
Cross-Sectional Studies
Female
Gastrointestinal Diseases - chemically induced
Guideline Adherence
Humans
Lumbar Vertebrae
Male
Middle Aged
Original
Practice Patterns, Physicians
Prevalence
Retrospective Studies
Risk Assessment
Risk Factors
Spinal Diseases - complications
Spinal Diseases - drug therapy
정형외과학
Cardiovascular disease
Gastrointestinal disorder
Non-steroidal anti-inflammatory agents
Spine disease
Risk assessment
ISSN:2005-291X, 2005-4408, 2005-4408
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Shrnutí:Limited information is available about the proportion of patients with degenerative lumbar spinal disease (DLSD) who have gastrointestinal (GI) and cardiovascular (CV) risk factors. Many DLSD patients are prescribed nonsteroidal anti-inflammatory drugs (NSAIDs) that are known to carry risks to the GI and CV systems by increasing GI bleeding and thromboembolic events. This study aimed to measure the prevalence of GI and CV risk in patients with DLSD and to ascertain whether the prescription of NSAIDs is in line with current guidelines. This study included 153 patients with symptomatic DLSD who were planning to undergo lumbar spinal surgery. The GI profile was checked using the GI Standardized Calculator of Risk for Event system and CV risk was evaluated using the presence of metabolic syndrome. The conformity of the prescription of NSAIDs was investigated according to the recommendations in current guidelines. More than half of the patients (59.5%) had high or very high GI risk, and 66% of the patients were diagnosed with metabolic syndrome, which corresponds with CV risk. The rate of simultaneous GI and CV risk was 40.5% (n = 62 / 153; gastrointestinal Standardized Calculator of Risk for Event, > high and metabolic syndrome, yes). The actual prescription of NSAIDs was not in accordance with current guidelines. Two out of 3 patients had GI or CV risk factors, and approximately 40% of patients had both. Detailed assessment of GI and CV risk in patients with DLSD by using effective evaluation tools is mandatory for optimal medical treatment.
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https://www.ecios.org/search.php?where=aview&id=10.4055/cios20021&code=0157CIOS&vmode=FULL
ISSN:2005-291X
2005-4408
2005-4408
DOI:10.4055/cios20021