Control of murine brown adipocyte development by GATA6

Brown adipose tissue (BAT) is a thermogenic organ that protects animals against hypothermia and obesity. BAT derives from the multipotent paraxial mesoderm; however, the identity of embryonic brown fat progenitor cells and regulators of adipogenic commitment are unclear. Here, we performed single-ce...

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Veröffentlicht in:Developmental cell Jg. 58; H. 21; S. 2195
Hauptverfasser: Jun, Seoyoung, Angueira, Anthony R, Fein, Ethan C, Tan, Josephine M E, Weller, Angela H, Cheng, Lan, Batmanov, Kirill, Ishibashi, Jeff, Sakers, Alexander P, Stine, Rachel R, Seale, Patrick
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 06.11.2023
Schlagworte:
Adipocytes, Brown - metabolism
Adipogenesis
Adipose Tissue, Brown - metabolism
Animals
Dipeptidyl Peptidase 4 - metabolism
Mice
Obesity - metabolism
Thermogenesis - genetics
DPP4
brown adipogenesis
brown adipocyte
GATA6
UCP1
adipose tissue
EBF2
progenitor
brown adipocyte development
ISSN:1878-1551, 1878-1551
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Zusammenfassung:Brown adipose tissue (BAT) is a thermogenic organ that protects animals against hypothermia and obesity. BAT derives from the multipotent paraxial mesoderm; however, the identity of embryonic brown fat progenitor cells and regulators of adipogenic commitment are unclear. Here, we performed single-cell gene expression analyses of mesenchymal cells during mouse embryogenesis with a focus on BAT development. We identified cell populations associated with the development of BAT, including Dpp4+ cells that emerge at the onset of adipogenic commitment. Immunostaining and lineage-tracing studies show that Dpp4+ cells constitute the BAT fascia and contribute minorly as adipocyte progenitors. Additionally, we identified the transcription factor GATA6 as a marker of brown adipogenic progenitor cells. Deletion of Gata6 in the brown fat lineage resulted in a striking loss of BAT. Together, these results identify progenitor and transitional cells in the brown adipose lineage and define a crucial role for GATA6 in BAT development.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1878-1551
1878-1551
DOI:10.1016/j.devcel.2023.08.003