Recent developments of C-4 substituted coumarin derivatives as anticancer agents

Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Coumarin scaffold...

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Bibliographic Details
Published in:European journal of medicinal chemistry Vol. 119; pp. 141 - 168
Main Authors: Dandriyal, Jyoti, Singla, Ramit, Kumar, Manvendra, Jaitak, Vikas
Format: Journal Article
Language:English
Published: France Elsevier Masson SAS 25.08.2016
Subjects:
Animals
Anticancer
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
C-4 substituted coumarin
Coumarins - chemical synthesis
Coumarins - chemistry
Coumarins - pharmacology
Humans
Mechanism of action
SAR
Synthesis
C-4 substituted coumarin
Synthesis
Anticancer
Mechanism of action
SAR
ISSN:0223-5234, 1768-3254
Online Access:Get full text
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Summary:Cancer is a prominent cause of death in global. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Coumarin scaffold became an attractive subject due to their broad spectrum of pharmacological activities. Coumarin derivatives extensively explored for anticancer activities as it possesses minimum side effect along with multi-drug reversal activity. Coumarin derivatives can act by various mechanisms on different tumor cell lines depending on substitution pattern of the core structure of coumarin. Substitution on coumarin nucleus leads to the search for more potent compounds. In this review, we have made an effort to give a synthetic strategy for the preparation of C-4 substituted coumarin derivatives as anticancer agents based on their mechanism of action and also discuss the SAR of the most active compound. [Display omitted] •C-4 substituted coumarin as anticancer agent.•Targets for the anticancer activities of each coumarin derivative.•Structure activity relationship of C-4 substituted derivatives.•In-silico and in-vitro study of the C-4 substituted coumarins.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2016.03.087