A Systematic Review of the Potential of Pichia pastoris (Komagataella phaffii) as an Alternative Host for Biologics Production

The methylotrophic yeast Pichia pastoris is garnering interest as a chassis cell factory for the manufacture of recombinant proteins because it effectively satisfies the requirements of both laboratory and industrial set up. The optimisation of P. pastoris cultivation is still necessary due to strai...

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Bibliographic Details
Published in:	Molecular biotechnology Vol. 66; no. 7; pp. 1621 - 1639
Main Authors:	Vijayakumar, Vijay Elakkya, Venkataraman, Krishnan
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.07.2024 Springer Nature B.V
Subjects:	alternative hosts Biochemistry Biological Products - metabolism Biological Techniques Biotechnology Cell Biology Chemistry Chemistry and Materials Science CRISPR CRISPR-Cas Systems Gene dosage Genetic diversity Genetic engineering Genetic Engineering - methods Human Genetics Komagataella pastoris manufacturing Methanol peptides Pichia Pichia - genetics Pichia - metabolism Pichia pastoris Process engineering Protein engineering Protein Science Proteins Recombinant Proteins - genetics Recombinant Proteins - metabolism Review Saccharomycetales - genetics Saccharomycetales - metabolism Systematic review therapeutics Yeast yeasts 2A peptide system Proteolysis Secretion Recombinant proteins CRISPR/Cas Promoters Codon optimization Pichia pastoris
ISSN:	1073-6085, 1559-0305, 1559-0305
Online Access:	Get full text
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