Electropsun Polycaprolactone Fibres in Bone Tissue Engineering: A Review

Regeneration of bone tissue requires novel load bearing, biocompatible materials that support adhesion, spreading, proliferation, differentiation, mineralization, ECM production and maturation of bone-forming cells. Polycaprolactone (PCL) has many advantages as a biomaterial for scaffold production...

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Bibliographic Details
Published in:Molecular biotechnology Vol. 63; no. 5; pp. 363 - 388
Main Authors: Siddiqui, Nadeem, Kishori, Braja, Rao, Saranya, Anjum, Mohammad, Hemanth, Venkata, Das, Swati, Jabbari, Esmaiel
Format: Journal Article
Language:English
Published: New York Springer US 01.05.2021
Springer Nature B.V
Subjects:
adhesion
Biochemistry
Biocompatibility
biocompatible materials
Biodegradation
Biological Techniques
Biomaterials
Biomedical materials
Biotechnology
Bone biomaterials
Bone growth
Bones
Cell Biology
Cell proliferation
Chemistry
Chemistry and Materials Science
Extracellular matrix
Fibers
Human Genetics
hydrophilicity
Mechanical properties
Mineralization
Nanofibers
Polycaprolactone
Porosity
Porous media
Protein Science
Regeneration
Regeneration (physiology)
Review
Scaffolds
surface area
temperature
Tissue engineering
Electrospinning
Biocompatibility
Polymer composites
Bone tissue engineering
Scaffold
Polycaprolactone
ISSN:1073-6085, 1559-0305, 1559-0305
Online Access:Get full text
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Summary:Regeneration of bone tissue requires novel load bearing, biocompatible materials that support adhesion, spreading, proliferation, differentiation, mineralization, ECM production and maturation of bone-forming cells. Polycaprolactone (PCL) has many advantages as a biomaterial for scaffold production including tuneable biodegradation, relatively high mechanical toughness at physiological temperature. Electrospinning produces nanofibrous porous matrices that mimic many properties of natural tissue extracellular matrix with regard to surface area, porosity and fibre alignment. The biocompatibility and hydrophilicity of PCL nanofibres can be improved by combining PCL with other biomaterials to form composite scaffolds for bone regeneration. This work reviews the most recent research on synthesis, characterization and cellular response to nanofibrous PCL scaffolds and the composites of PCL with other natural and synthetic materials for bone tissue engineering.
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ISSN:1073-6085
1559-0305
1559-0305
DOI:10.1007/s12033-021-00311-0