Integrating DNA sequencing and transcriptomic data for association analyses of low-frequency variants and lipid traits

Transcriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and transcriptomic data to showcase their improved statistical power of identifying gene-trait associations while, importantly, offering further biological insights. TWAS have thus far focused on common va...

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Vydané v:	Human molecular genetics Ročník 29; číslo 3; s. 515
Hlavní autori:	Yang, Tianzhong, Wu, Chong, Wei, Peng, Pan, Wei
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.02.2020
Predmet:	Adolescent Adult Aged Aged, 80 and over Child Computational Biology Female Gene Expression Profiling Genetic Predisposition to Disease Genome-Wide Association Study Humans Linkage Disequilibrium Lipids - genetics Longitudinal Studies Male Middle Aged Phenotype Polymorphism, Single Nucleotide Quantitative Trait Loci Transcriptome Twin Studies as Topic United Kingdom United States Whole Genome Sequencing Young Adult United States United Kingdom
ISSN:	1460-2083, 1460-2083
On-line prístup:	Zistit podrobnosti o prístupe
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