Advances in the study of LNPs for mRNA delivery and clinical applications

Messenger ribonucleic acid (mRNA) was discovered in 1961 as an intermediary for transferring genetic information from DNA to ribosomes for protein synthesis. The COVID-19 pandemic brought worldwide attention to mRNA vaccines. The emergency use authorization of two COVID-19 mRNA vaccines, BNT162b2 an...

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Bibliographic Details
Published in:	Virus genes Vol. 60; no. 6; pp. 577 - 591
Main Authors:	Wang, Bili, Shen, Biao, Xiang, Wenqing, Shen, Hongqiang
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.12.2024 Springer Nature B.V
Subjects:	2019-nCoV Vaccine mRNA-1273 Biocompatibility Biodegradability Biomedical and Life Sciences Biomedicine Cardiovascular diseases Cell size Cholesterol COVID-19 - prevention & control COVID-19 infection COVID-19 vaccines COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology DNA DNA biosynthesis DNA vaccines Drug delivery Drug development genes Humans Infectious diseases Lipid bilayers Lipids - chemistry Liposomes liver Liver cancer Liver diseases Medical Microbiology mRNA mRNA Vaccines Nanoparticles Nanoparticles - chemistry pH effects Phospholipids Plant Sciences Polyethylene glycol Protein biosynthesis protein synthesis Review Paper Ribosomes RNA RNA, Messenger - genetics SARS-CoV-2 - genetics therapeutics Transcription Vaccine development Vaccine efficacy vaccines Vascular diseases Virology viruses mRNA vaccines mRNA delivery LNPs Clinical applications
ISSN:	0920-8569, 1572-994X, 1572-994X
Online Access:	Get full text
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