Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome

Slow-twitch muscle fibers of the zebrafish myotome undergo a unique set of morphogenetic cell movements. During embryogenesis, slow-twitch muscle derives from the adaxial cells, a layer of paraxial mesoderm that differentiates medially within the myotome, immediately adjacent to the notochord. Subse...

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Vydané v:Developmental cell Ročník 5; číslo 6; s. 865
Hlavní autori: Cortés, Fernando, Daggett, David, Bryson-Richardson, Robert J, Neyt, Christine, Maule, John, Gautier, Phillipe, Hollway, Georgina E, Keenan, David, Currie, Peter D
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.12.2003
Predmet:
Animals
Cadherins - genetics
Cadherins - metabolism
Cell Adhesion - physiology
Cell Movement - physiology
Gene Expression Regulation, Developmental
Muscle Fibers, Slow-Twitch - cytology
Muscle Fibers, Slow-Twitch - physiology
Muscle, Skeletal - cytology
Muscle, Skeletal - embryology
Muscle, Skeletal - physiology
Mutagenesis, Site-Directed
Zebrafish
ISSN:1534-5807
On-line prístup:Zistit podrobnosti o prístupe
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Shrnutí:Slow-twitch muscle fibers of the zebrafish myotome undergo a unique set of morphogenetic cell movements. During embryogenesis, slow-twitch muscle derives from the adaxial cells, a layer of paraxial mesoderm that differentiates medially within the myotome, immediately adjacent to the notochord. Subsequently, slow-twitch muscle cells migrate through the entire myotome, coming to lie at its most lateral surface. Here we examine the cellular and molecular basis for slow-twitch muscle cell migration. We show that slow-twitch muscle cell morphogenesis is marked by behaviors typical of cells influenced by differential cell adhesion. Dynamic and reciprocal waves of N-cadherin and M-cadherin expression within the myotome, which correlate precisely with cell migration, generate differential adhesive environments that drive slow-twitch muscle cell migration through the myotome. Removing or altering the expression of either protein within the myotome perturbs migration. These results provide a definitive example of homophilic cell adhesion shaping cellular behavior during vertebrate development.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1534-5807
DOI:10.1016/S1534-5807(03)00362-9