Leukemia inhibitory factor receptor inhibition by EC359 reduces atherosclerotic stenosis grade in Ldlr−/− mice

Cytokines are involved in all stages of atherosclerosis, generally contributing to disease progression. Previously, members of the Interleukin (IL)-6 cytokine family, such as IL-6, oncostatin M, and cardiotrophin-1, have been extensively studied in atherosclerosis. However, the role of leukemia inhi...

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Bibliographic Details
Published in:	European journal of pharmacology Vol. 985; p. 177121
Main Authors:	Hemme, Esmeralda, Depuydt, Marie A.C., van Santbrink, Peter J., Wezel, Anouk, Smeets, Harm J., Foks, Amanda C., Kuiper, Johan, Bot, Ilze
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.12.2024
Subjects:	Adhesion molecules Animals Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - metabolism Atherosclerosis - pathology Cholesterol Cytokines Endothelial Cells - drug effects Endothelial Cells - metabolism Female Humans Inflammation Leukemia inhibitory factor Leukemia Inhibitory Factor - genetics Leukemia Inhibitory Factor - metabolism Leukemia Inhibitory Factor Receptor alpha Subunit - genetics Leukemia Inhibitory Factor Receptor alpha Subunit - metabolism Mast Cells - drug effects Mast Cells - metabolism Mice Mice, Inbred C57BL Mice, Knockout Plaque, Atherosclerotic - drug therapy Receptors, LDL - deficiency Receptors, LDL - genetics Adhesion molecules Inflammation Cytokines Leukemia inhibitory factor Cholesterol Atherosclerosis
ISSN:	0014-2999, 1879-0712, 1879-0712
Online Access:	Get full text
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