Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis

Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque, represent the major cause of morbidity and mortality in patients. Growing evidence suggests that plaque neovascularization is an important contributor to plaque growth and instability. The vessels’ immaturity, with...

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Bibliographic Details
Published in:European journal of pharmacology Vol. 816; pp. 107 - 115
Main Authors: Parma, Laura, Baganha, Fabiana, Quax, Paul H.A., de Vries, Margreet R.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 05.12.2017
Subjects:
Angiogenesis
Animals
Atherosclerosis
Hemorrhage - complications
Humans
Intraplaque hemorrhage
Molecular Imaging
Neovascularization, Pathologic - diagnostic imaging
Plaque neovessels
Plaque, Atherosclerotic - complications
Plaque, Atherosclerotic - diagnostic imaging
Plaque, Atherosclerotic - physiopathology
VEGF
Angiogenesis
Plaque neovessels
VEGF
Intraplaque hemorrhage
Atherosclerosis
ISSN:0014-2999, 1879-0712, 1879-0712
Online Access:Get full text
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Summary:Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque, represent the major cause of morbidity and mortality in patients. Growing evidence suggests that plaque neovascularization is an important contributor to plaque growth and instability. The vessels’ immaturity, with profound structural and functional abnormalities, leads to recurrent intraplaque hemorrhage. This review discusses new insights of atherosclerotic neovascularization, including the effects of leaky neovessels on intraplaque hemorrhage, both in experimental models and humans. Furthermore, modalities for in vivo imaging and therapeutic interventions to target plaque angiogenesis will be discussed.
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ISSN:0014-2999
1879-0712
1879-0712
DOI:10.1016/j.ejphar.2017.04.028