FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling

Cancer-associated fibroblasts (CAF) are components of the tumor microenvironment whose contributions to malignant progression are not fully understood. Here, we show that the fibroblast activation protein (FAP) triggers induction of a CAF subset with an inflammatory phenotype directed by STAT3 activ...

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Vydané v:	Cancer research (Chicago, Ill.) Ročník 76; číslo 14; s. 4124
Hlavní autori:	Yang, Xuguang, Lin, Yuli, Shi, Yinghong, Li, Bingji, Liu, Weiren, Yin, Wei, Dang, Yongjun, Chu, Yiwei, Fan, Jia, He, Rui
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 15.07.2016
Predmet:	Animals Cancer-Associated Fibroblasts - physiology Cell Movement Chemokine CCL2 - physiology Female Focal Adhesion Protein-Tyrosine Kinases - physiology Gelatinases - physiology Immune Tolerance Janus Kinase 2 - physiology Membrane Proteins - physiology Mice Mice, Inbred C57BL Receptors, Urokinase Plasminogen Activator - physiology Serine Endopeptidases - physiology Signal Transduction - physiology STAT3 Transcription Factor - physiology Tumor Microenvironment
ISSN:	1538-7445, 1538-7445
On-line prístup:	Zistit podrobnosti o prístupe
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