FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling

Cancer-associated fibroblasts (CAF) are components of the tumor microenvironment whose contributions to malignant progression are not fully understood. Here, we show that the fibroblast activation protein (FAP) triggers induction of a CAF subset with an inflammatory phenotype directed by STAT3 activ...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 76; H. 14; S. 4124
Hauptverfasser:	Yang, Xuguang, Lin, Yuli, Shi, Yinghong, Li, Bingji, Liu, Weiren, Yin, Wei, Dang, Yongjun, Chu, Yiwei, Fan, Jia, He, Rui
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.07.2016
Schlagworte:	Animals Cancer-Associated Fibroblasts - physiology Cell Movement Chemokine CCL2 - physiology Female Focal Adhesion Protein-Tyrosine Kinases - physiology Gelatinases - physiology Immune Tolerance Janus Kinase 2 - physiology Membrane Proteins - physiology Mice Mice, Inbred C57BL Receptors, Urokinase Plasminogen Activator - physiology Serine Endopeptidases - physiology Signal Transduction - physiology STAT3 Transcription Factor - physiology Tumor Microenvironment
ISSN:	1538-7445, 1538-7445
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!