cHCC‐CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation

Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as “combined (or mixed) hepatocellular‐cholangiocarcinoma.” These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell...

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Vydané v:Hepatology (Baltimore, Md.) Ročník 68; číslo 1; s. 113 - 126
Hlavní autori: Brunt, Elizabeth, Aishima, Shinichi, Clavien, Pierre‐Alain, Fowler, Kathryn, Goodman, Zachary, Gores, Gregory, Gouw, Annette, Kagen, Alex, Klimstra, David, Komuta, Mina, Kondo, Fukuo, Miksad, Rebecca, Nakano, Masayuki, Nakanuma, Yasuni, Ng, Irene, Paradis, Valerie, Nyun Park, Young, Quaglia, Alberto, Roncalli, Massimo, Roskams, Tania, Sakamoto, Michiie, Saxena, Romil, Sempoux, Christine, Sirlin, Claude, Stueck, Ashley, Thung, Swan, Tsui, W.M.S., Wang, Xin‐Wei, Wee, Aileen, Yano, Hirohisa, Yeh, Matthew, Zen, Yoh, Zucman‐Rossi, Jessica, Theise, Neil
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Wolters Kluwer Health, Inc 01.07.2018
Predmet:
Aged
Carcinoma
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - pathology
Cholangiocarcinoma
Cholangiocarcinoma - diagnosis
Cholangiocarcinoma - pathology
Diagnosis
Female
Hepatology
Humans
Liver
Liver - pathology
Liver cancer
Liver Neoplasms - classification
Liver Neoplasms - diagnosis
Liver Neoplasms - pathology
Radiography
Stem cells
Terminology
Terminology as Topic
Tumors
ISSN:0270-9139, 1527-3350, 1527-3350
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Popis
Shrnutí:Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as “combined (or mixed) hepatocellular‐cholangiocarcinoma.” These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell origin and perhaps because of greater frequency and clinical recognition. Currently, because of a lack of common terminology in the literature, effective treatment and predictable outcome data have been challenging to accrue. This article represents a consensus document from an international community of pathologists, radiologists, and clinicians who have studied and reported on these tumors and recommends a working terminology for diagnostic and research approaches for further study and evaluation. Conclusion: It is recommended that diagnosis is based on routine histopathology with hematoxylin and eosin (H&E); immunostains are supportive, but not essential for diagnosis. (Hepatology 2018;68:113‐126).
Bibliografia:combined HCC‐CCA (cHCC‐CCA)
was agreed upon.
Disclaimer: The manuscript was neither submitted nor endorsed by the AASLD Governing Board.
The authors of this article met in November 2015 and 2016 at the initiative of Drs. Theise and Brunt. The term
Potential conflict of interest: Dr. Sirlin is on the speakers' bureau for and received grants from GE. He is on the speakers' bureau for Bayer. He received grants from Siemens. Dr. Kagen consults for and is on the speakers' bureau for Bayer.
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ISSN:0270-9139
1527-3350
1527-3350
DOI:10.1002/hep.29789