Microvascular Impairment in Patients With Cerebral Small Vessel Disease Assessed With Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Study
In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial tr...
Uložené v:
| Vydané v: | Frontiers in aging neuroscience Ročník 14; s. 871612 |
|---|---|
| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Switzerland
Frontiers Research Foundation
19.05.2022
Frontiers Media S.A |
| Predmet: | |
| ISSN: | 1663-4365, 1663-4365 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL. |
|---|---|
| AbstractList | In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL.In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL. In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL. In this pilot study we investigated microvascular impairment in cerebral small vessel disease (CSVD) patients using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMH), lacunes, enlarged perivascular spaces (EPVS) and cerebral microbleeds (CMB). Here we found, that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMH, lacunes, EPVS and CMB. Additionally, we observed a longer mean T1eff of grey matter and WM in CSVD patients compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated to CSVD burden, whereas lobar lacunes and CMB contributed primary to this relation compared to EPVS of the centrum semiovale. Our results complement previous findings of CSVD related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue, and by an increased T1eff as potential indication of impaired clearance rates using ASL. |
| Author | Neumann, Katja Günther, Matthias Schreiber, Stefanie Düzel, Emrah |
| AuthorAffiliation | 2 Fraunhofer Institute for Digital Medicine MEVIS , Bremen , Germany 7 Center for Behavioral Brain Science , Magdeburg , Germany 6 Institute of Cognitive Neuroscience, University College London , London , United Kingdom 1 German Center for Neurodegenerative Diseases (DZNE) , Magdeburg , Germany 4 mediri GmbH , Heidelberg , Germany 8 Department of Neurology, Otto-von-Guericke University Magdeburg , Magdeburg , Germany 3 MR-Imaging and Spectroscopy, University of Bremen , Bremen , Germany 5 Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg , Magdeburg , Germany |
| AuthorAffiliation_xml | – name: 5 Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg , Magdeburg , Germany – name: 4 mediri GmbH , Heidelberg , Germany – name: 2 Fraunhofer Institute for Digital Medicine MEVIS , Bremen , Germany – name: 1 German Center for Neurodegenerative Diseases (DZNE) , Magdeburg , Germany – name: 3 MR-Imaging and Spectroscopy, University of Bremen , Bremen , Germany – name: 6 Institute of Cognitive Neuroscience, University College London , London , United Kingdom – name: 8 Department of Neurology, Otto-von-Guericke University Magdeburg , Magdeburg , Germany – name: 7 Center for Behavioral Brain Science , Magdeburg , Germany |
| Author_xml | – sequence: 1 givenname: Katja surname: Neumann fullname: Neumann, Katja – sequence: 2 givenname: Matthias surname: Günther fullname: Günther, Matthias – sequence: 3 givenname: Emrah surname: Düzel fullname: Düzel, Emrah – sequence: 4 givenname: Stefanie surname: Schreiber fullname: Schreiber, Stefanie |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35663571$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1Uttq3DAQNSWlSdN8QF-KoC992a1kybLVh8KyvS1saOiW9lHI9tjRIksbyQ7kR_q9nc0mJQl0EGgknTmay3mZHfngIcteMzrnvFLvO296O89pns-rkkmWP8tOmJR8Jrgsjh74x9lZSluKxjmlRfUiO-YFPhYlO8n-nNsmhmuTmsmZSFbDztg4gB-J9eTCjBbdRH7b8ZIsIUIdjSObwThHfkFK4Mgnm8AkIAs84WoP2EUcIdo9doc8a1ODs74n56b3MNqG_IAUvPEN4I9Yhu8_kAW5sC6MZDNO7c2r7HlnXIKzu_0023z5_HP5bbb-_nW1XKxnjaBVPoOmEazgbd3VVadYLUEJQ1tWFrVgSnayy1tTdrwssHbgirJaQcu5YEZxw0-z1YG1DWard9EOJt7oYKy-vQix1yZiug40Rle1kG2dUyaoKetCMmVEVcm2VUpS5Pp44NpN9QBtg33DXj0iffzi7aXuw7VWODvK9wTv7ghiuJogjXqwqQHnjIcwJZ3LUlCqRFUi9O0T6DZM0WOjEIWmZFFUiHrzMKN_qdwPHwHlAYAKSClCpxs74sjDPkHrNKN6rzR9qzS9V5o-KA0j2ZPIe_L_x_wFAW7X_A |
| CitedBy_id | crossref_primary_10_1159_000541700 crossref_primary_10_1016_j_brainresbull_2025_111525 crossref_primary_10_1186_s12987_023_00499_0 crossref_primary_10_3390_cells12060957 crossref_primary_10_1038_s41598_025_03885_w crossref_primary_10_1016_j_nbd_2025_107025 crossref_primary_10_7759_cureus_92760 crossref_primary_10_2174_0118744400389049250723091323 crossref_primary_10_1055_a_2190_8957 crossref_primary_10_3389_fnagi_2025_1538850 crossref_primary_10_4103_1673_5374_385864 crossref_primary_10_3389_fnins_2025_1672726 crossref_primary_10_3389_fnins_2025_1526897 crossref_primary_10_1177_0271678X251333933 |
| Cites_doi | 10.1016/j.neuroimage.2011.02.046 10.1038/s41582-020-0312-z 10.1001/jamaneurol.2016.0832 10.3389/fneur.2020.567232 10.1007/s10334-014-0480-1 10.1093/brain/awab478 10.1177/0271678X16662891 10.1002/jmri.25367 10.1002/mrm.22641 10.1002/mrm.1910150117 10.1002/mrm.1910380211 10.1177/2058460115609635 10.1103/PhysRev.70.460 10.1161/01.STR.28.3.652 10.1161/STROKEAHA.109.564914 10.1016/j.jns.2016.11.021 10.1093/braincomms/fcab127 10.1109/TSP.2008.2005752 10.1212/WNL.0000000000002362 10.1212/WNL.0000000000004665 10.12659/AOT.889188 10.1109/42.906424 10.1212/WNL.0000000000011046 10.1002/mrm.22320 10.3389/fneur.2020.611485 10.1371/journal.pone.0164112 10.1126/science.1241224 10.1002/mrm.1910400308 10.1161/STROKEAHA.107.513176 10.1016/S1474-4422(13)70124-8 10.1016/S0140-6736(85)91447-3 10.1002/mrm.20178 10.1002/alz.12157 10.1002/mrm.28839 10.1002/mrm.10180 10.1016/j.nicl.2019.101897 10.1016/j.neurobiolaging.2018.01.006 10.1002/mrm.20580 10.1212/WNL.0b013e3181c34a7d 10.1016/j.neuroimage.2008.12.027 10.1016/j.jcmg.2019.03.018 10.3389/fneur.2013.00060 10.1002/mrm.1910400303 10.1016/j.mri.2016.08.021 10.1002/mrm.24550 10.1007/s10334-019-00818-3 10.1016/j.neurobiolaging.2015.06.024 10.1002/1531-8249(199912)46:6<827::AID-ANA4>3.0.CO;2-H 10.1212/WNL.0b013e3181dad605 10.1002/dad2.12053 10.1016/j.neuroimage.2011.09.015 10.1073/pnas.89.1.212 10.1002/jmri.26892 10.2214/ajr.149.2.351 10.1016/j.neuroimage.2004.07.051 10.1152/physrev.00031.2020 10.1006/nimg.2002.1132 10.1101/cshperspect.a006338 10.1038/s41593-021-00904-7 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 Neumann, Günther, Düzel and Schreiber. 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2022 Neumann, Günther, Düzel and Schreiber. 2022 Neumann, Günther, Düzel and Schreiber |
| Copyright_xml | – notice: Copyright © 2022 Neumann, Günther, Düzel and Schreiber. – notice: 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © 2022 Neumann, Günther, Düzel and Schreiber. 2022 Neumann, Günther, Düzel and Schreiber |
| DBID | AAYXX CITATION NPM 3V. 7X7 7XB 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.3389/fnagi.2022.871612 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni Edition) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Science Database Biological Science Database Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef PubMed Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1663-4365 |
| ExternalDocumentID | oai_doaj_org_article_3e38b46db20140a7b5619a4886dd9960 PMC9161030 35663571 10_3389_fnagi_2022_871612 |
| Genre | Journal Article |
| GeographicLocations | Germany |
| GeographicLocations_xml | – name: Germany |
| GrantInformation_xml | – fundername: ; |
| GroupedDBID | --- 53G 5VS 7X7 8FE 8FH 8FI 9T4 AAFWJ AAYXX ABIVO ABUWG ACGFO ACGFS ADBBV ADRAZ AEGXH AENEX AFKRA AFPKN AIAGR ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI CITATION DIK E3Z EIHBH F5P FYUFA GROUPED_DOAJ GX1 HCIFZ HYE KQ8 LK8 M2P M48 M7P M~E O5R O5S OK1 PGMZT PIMPY PQQKQ PROAC RNS RPM TR2 UKHRP 88I 8FJ ACXDI ALIPV CCPQU DWQXO GNUQQ HMCUK IPNFZ NPM PHGZT RIG 3V. 7XB 8FK K9. PHGZM PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U 7X8 5PM |
| ID | FETCH-LOGICAL-c4082-ecc4153dbfb8f91b6e94a0d175b4196f6f2da7f375033e3901b9ed3341a93a3 |
| IEDL.DBID | DOA |
| ISSN | 1663-4365 |
| IngestDate | Fri Oct 03 12:51:59 EDT 2025 Thu Aug 21 18:06:24 EDT 2025 Fri Sep 05 14:27:14 EDT 2025 Tue Oct 07 06:55:19 EDT 2025 Thu Apr 03 07:08:21 EDT 2025 Sat Nov 29 06:11:45 EST 2025 Tue Nov 18 22:10:29 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | T1-relaxation magnetic resonance imaging perfusion cerebral blood flow cerebral small vessel disease clearance arterial spin labeling arterial transit time |
| Language | English |
| License | Copyright © 2022 Neumann, Günther, Düzel and Schreiber. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4082-ecc4153dbfb8f91b6e94a0d175b4196f6f2da7f375033e3901b9ed3341a93a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Edited by: Zhendong Liu, Shandong First Medical University, China Reviewed by: Rahul Pratap Kotian, Gulf Medical University, United Arab Emirates; Xiaoniu Liang, Fudan University, China; Antonio Coca, University of Barcelona, Spain This article was submitted to Neuroinflammation and Neuropathy, a section of the journal Frontiers in Aging Neuroscience |
| OpenAccessLink | https://doaj.org/article/3e38b46db20140a7b5619a4886dd9960 |
| PMID | 35663571 |
| PQID | 2666696558 |
| PQPubID | 4424411 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_3e38b46db20140a7b5619a4886dd9960 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9161030 proquest_miscellaneous_2674009487 proquest_journals_2666696558 pubmed_primary_35663571 crossref_citationtrail_10_3389_fnagi_2022_871612 crossref_primary_10_3389_fnagi_2022_871612 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-05-19 |
| PublicationDateYYYYMMDD | 2022-05-19 |
| PublicationDate_xml | – month: 05 year: 2022 text: 2022-05-19 day: 19 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Lausanne |
| PublicationTitle | Frontiers in aging neuroscience |
| PublicationTitleAlternate | Front Aging Neurosci |
| PublicationYear | 2022 |
| Publisher | Frontiers Research Foundation Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Research Foundation – name: Frontiers Media S.A |
| References | Fazekas (B20) 1987; 149 Fleck (B21) 1985; 1 Smith (B46) 2004; 23 Charidimou (B11); 73 Rane (B39) 2018; 65 Macintosh (B32) 2013; 4 Günther (B25) 2005; 54 Pantoni (B36) 1997; 28 Chappell (B8) 2010; 63 Dijk (B16) 2008; 39 Bloch (B2) 1946; 70 Silva (B45) 1997; 38 Mutsaerts (B35) 2015; 28 Zhang (B58) 2013; 70 Wong (B55) 1998; 40 Bojorquez (B3) 2017; 35 Zlokovic (B60) 2020; 16 Gertje (B22) 2021; 96 Gregoire (B23) 2009; 73 Williams (B54) 1992; 89 Xie (B56) 2013; 342 Charidimou (B9); 86 Zhang (B57) 2021; 2021 Eide (B19) 2015; 4 Patenaude (B38) 2011; 56 Doubal (B18) 2010; 41 Shi (B44) 2016; 36 Joseph (B29) 2020; 33 Lu (B31) 2004; 52 Ssali (B47) 2016; 11 Dolui (B17) 2019; 23 Jenkinson (B28) 2012; 62 Charidimou (B10); 89 Groves (B24) 2009; 45 Vockert (B50) 2021; 3 Dai (B14) 2017; 45 Schaeffer (B43) 2021; 24 Taoka (B49) 2020; 51 Chappell (B6) 2011; 65 Rozga (B42) 2013; 18 Rasmussen (B40) 2021; 102 Chappell (B7) 2009; 57 de Leeuw (B15) 1999; 46 Wenn (B53) 1990; 13 Chen (B13) 2020; 11 Wardlaw (B52) 2013; 12 Zhang (B59) 2001; 20 Jenkinson (B27) 2002; 17 Parkes (B37) 2002; 48 Buxton (B4) 1998; 40 Mucke (B33) 2012; 2 Agarwal (B1) 2020; 11 Charidimou (B12); 372 Carare (B5) 2020; 12 Mugler (B34) 1990; 15 Staals (B48) 2015; 36 Rosmini (B41) 2019; 12 Linn (B30) 2010; 74 Wardlaw (B51) 2020; 16 Jackson (B26) 2021; 2021 |
| References_xml | – volume: 56 start-page: 907 year: 2011 ident: B38 article-title: A Bayesian model of shape and appearance for subcortical brain segmentation publication-title: Neuroimage doi: 10.1016/j.neuroimage.2011.02.046 – volume: 16 start-page: 137 year: 2020 ident: B51 article-title: Perivascular spaces in the brain: anatomy, physiology and pathology publication-title: Nat. Rev. Neurol doi: 10.1038/s41582-020-0312-z – volume: 73 start-page: 994 ident: B11 article-title: Total magnetic resonance imaging burden of small vessel disease in cerebral amyloid angiopathy: an imaging-pathologic study of concept validation publication-title: J. Am Med. Assoc. Neurol doi: 10.1001/jamaneurol.2016.0832 – volume: 11 start-page: 567232 year: 2020 ident: B13 article-title: Correlation between internal carotid artery tortuosity and imaging of cerebral small vessel disease publication-title: Front. Neurol doi: 10.3389/fneur.2020.567232 – volume: 28 start-page: 427 year: 2015 ident: B35 article-title: Reproducibility of pharmacological ASL using sequences from different vendors: implications for multicenter drug studies publication-title: Magma doi: 10.1007/s10334-014-0480-1 – volume: 2021 start-page: awab478 year: 2021 ident: B26 article-title: APOE4 derived from astrocytes leads to blood-brain barrier impairment publication-title: Brain doi: 10.1093/brain/awab478 – volume: 36 start-page: 1653 year: 2016 ident: B44 article-title: Cerebral blood flow in small vessel disease: a systematic review and meta-analysis publication-title: J. Cereb. Blood Flow Metab doi: 10.1177/0271678X16662891 – volume: 13 start-page: 67 year: 1990 ident: B53 article-title: Arterial tortuosity publication-title: Austral. Phys. Eng. Sci. Med – volume: 45 start-page: 472 year: 2017 ident: B14 article-title: Effects of arterial transit delay on cerebral blood flow quantification using arterial spin labeling in an elderly cohort publication-title: J. Magn. Reson. Imag doi: 10.1002/jmri.25367 – volume: 65 start-page: 1173 year: 2011 ident: B6 article-title: Partial volume correction of multiple inversion time arterial spin labeling MRI data publication-title: Magn. Reson. Med doi: 10.1002/mrm.22641 – volume: 15 start-page: 152 year: 1990 ident: B34 article-title: Three-dimensional magnetization-prepared rapid gradient-echo imaging (3D MP RAGE) publication-title: Magn. Reson. Med doi: 10.1002/mrm.1910150117 – volume: 38 start-page: 232 year: 1997 ident: B45 article-title: Evidence for the exchange of arterial spin-labeled water with tissue water in rat brain from diffusion-sensitized measurements of perfusion publication-title: Magn. Reson. Med doi: 10.1002/mrm.1910380211 – volume: 4 start-page: 2058460115609635 year: 2015 ident: B19 article-title: MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain publication-title: Acta Radiol. Open doi: 10.1177/2058460115609635 – volume: 70 start-page: 460 year: 1946 ident: B2 article-title: Nuclear induction publication-title: Phys. Rev doi: 10.1103/PhysRev.70.460 – volume: 28 start-page: 652 year: 1997 ident: B36 article-title: Pathogenesis of leukoaraiosis publication-title: Stroke doi: 10.1161/01.STR.28.3.652 – volume: 41 start-page: 450 year: 2010 ident: B18 article-title: Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease publication-title: Stroke doi: 10.1161/STROKEAHA.109.564914 – volume: 372 start-page: 178 ident: B12 article-title: The Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS): development and assessment of reliability publication-title: J. Neurol. Sci doi: 10.1016/j.jns.2016.11.021 – volume: 3 start-page: fcab127 year: 2021 ident: B50 article-title: Hippocampal vascularization patterns exert local and distant effects on brain structure but not vascular pathology in old age publication-title: Brain Commun doi: 10.1093/braincomms/fcab127 – volume: 57 start-page: 223 year: 2009 ident: B7 article-title: Variational Bayesian inference for a nonlinear forward model publication-title: Trans. Sig. Proc doi: 10.1109/TSP.2008.2005752 – volume: 86 start-page: 505 ident: B9 article-title: White matter hyperintensity patterns in cerebral amyloid angiopathy and hypertensive arteriopathy publication-title: Neurology doi: 10.1212/WNL.0000000000002362 – volume: 89 start-page: 2128 ident: B10 article-title: Cortical superficial siderosis multifocality in cerebral amyloid angiopathy: a prospective study publication-title: Neurology doi: 10.1212/WNL.0000000000004665 – volume: 18 start-page: 205 year: 2013 ident: B42 article-title: Human albumin: old, new, and emerging applications publication-title: Ann. Transplant doi: 10.12659/AOT.889188 – volume: 20 start-page: 45 year: 2001 ident: B59 article-title: Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm publication-title: IEEE Trans. Med. Imag doi: 10.1109/42.906424 – volume: 96 start-page: e193 year: 2021 ident: B22 article-title: Association of enlarged perivascular spaces and measures of small vessel and Alzheimer disease publication-title: Neurology doi: 10.1212/WNL.0000000000011046 – volume: 63 start-page: 1357 year: 2010 ident: B8 article-title: Separation of macrovascular signal in multi-inversion time arterial spin labelling MRI publication-title: Magn. Reson. Med doi: 10.1002/mrm.22320 – volume: 11 start-page: 611485 year: 2020 ident: B1 article-title: Cerebral vessels: an overview of anatomy, physiology, and role in the drainage of fluids and solutes publication-title: Front. Neurol doi: 10.3389/fneur.2020.611485 – volume: 11 start-page: e0164112 year: 2016 ident: B47 article-title: Mapping long-term functional changes in cerebral blood flow by arterial spin labeling publication-title: PLoS ONE doi: 10.1371/journal.pone.0164112 – volume: 342 start-page: 373 year: 2013 ident: B56 article-title: Sleep drives metabolite clearance from the adult brain publication-title: Science doi: 10.1126/science.1241224 – volume: 40 start-page: 383 year: 1998 ident: B4 article-title: A general kinetic model for quantitative perfusion imaging with arterial spin labeling publication-title: Magn. Reson. Med doi: 10.1002/mrm.1910400308 – volume: 39 start-page: 2712 year: 2008 ident: B16 article-title: Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences publication-title: Stroke doi: 10.1161/STROKEAHA.107.513176 – volume: 12 start-page: 822 year: 2013 ident: B52 article-title: Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration publication-title: Lancet Neurol doi: 10.1016/S1474-4422(13)70124-8 – volume: 1 start-page: 781 year: 1985 ident: B21 article-title: Increased vascular permeability: a major cause of hypoalbuminaemia in disease and injury publication-title: Lancet doi: 10.1016/S0140-6736(85)91447-3 – volume: 52 start-page: 679 year: 2004 ident: B31 article-title: Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla publication-title: Magn. Reson. Med doi: 10.1002/mrm.20178 – volume: 16 start-page: 1714 year: 2020 ident: B60 article-title: Vascular contributions to cognitive impairment and dementia (VCID): a report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop publication-title: Alzheimers Dement doi: 10.1002/alz.12157 – volume: 2021 start-page: 28839 year: 2021 ident: B57 article-title: Examination of optimized protocols for pCASL: Sensitivity to macrovascular contamination, flow dispersion, and prolonged arterial transit time publication-title: Magn. Reson. Med doi: 10.1002/mrm.28839 – volume: 48 start-page: 27 year: 2002 ident: B37 article-title: Improved accuracy of human cerebral blood perfusion measurements using arterial spin labeling: accounting for capillary water permeability publication-title: Magn. Reson. Med doi: 10.1002/mrm.10180 – volume: 23 start-page: 101897 year: 2019 ident: B17 article-title: Characterizing a perfusion-based periventricular small vessel region of interest publication-title: Neuroimage Clin doi: 10.1016/j.nicl.2019.101897 – volume: 65 start-page: 77 year: 2018 ident: B39 article-title: Quantitative cerebrovascular pathology in a community-based cohort of older adults publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2018.01.006 – volume: 54 start-page: 491 year: 2005 ident: B25 article-title: Single-shot 3D imaging techniques improve arterial spin labeling perfusion measurements publication-title: Magn. Reson. Med doi: 10.1002/mrm.20580 – volume: 73 start-page: 1759 year: 2009 ident: B23 article-title: The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds publication-title: Neurology doi: 10.1212/WNL.0b013e3181c34a7d – volume: 45 start-page: 795 year: 2009 ident: B24 article-title: Combined spatial and non-spatial prior for inference on MRI time-series publication-title: NeuroImage doi: 10.1016/j.neuroimage.2008.12.027 – volume: 12 start-page: 1888 year: 2019 ident: B41 article-title: The effect of blood composition on T1 mapping publication-title: JACC Cardiovasc. Imag doi: 10.1016/j.jcmg.2019.03.018 – volume: 4 start-page: 60 year: 2013 ident: B32 article-title: Magnetic resonance imaging to visualize stroke and characterize stroke recovery: a review publication-title: Front. Neurol doi: 10.3389/fneur.2013.00060 – volume: 40 start-page: 348 year: 1998 ident: B55 article-title: A theoretical and experimental comparison of continuous and pulsed arterial spin labeling techniques for quantitative perfusion imaging publication-title: Magn. Reson. Med doi: 10.1002/mrm.1910400303 – volume: 35 start-page: 69 year: 2017 ident: B3 article-title: What are normal relaxation times of tissues at 3 T? publication-title: Magn. Reson. Imag doi: 10.1016/j.mri.2016.08.021 – volume: 70 start-page: 1082 year: 2013 ident: B58 article-title: In vivo blood T(1) measurements at 1.5 T, 3 T, and 7 T publication-title: Magn. Reson. Med doi: 10.1002/mrm.24550 – volume: 33 start-page: 559 year: 2020 ident: B29 article-title: Pilot study utilizing MRI 3D TGSE PASL (arterial spin labeling) differentiating clearance rates of labeled protons in the CNS of patients with early Alzheimer disease from normal subjects publication-title: Magma doi: 10.1007/s10334-019-00818-3 – volume: 36 start-page: 2806 year: 2015 ident: B48 article-title: Total MRI load of cerebral small vessel disease and cognitive ability in older people publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2015.06.024 – volume: 46 start-page: 827 year: 1999 ident: B15 article-title: A follow-up study of blood pressure and cerebral white matter lesions publication-title: Ann. Neurol doi: 10.1002/1531-8249(199912)46:6<827::AID-ANA4>3.0.CO;2-H – volume: 74 start-page: 1346 year: 2010 ident: B30 article-title: Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy publication-title: Neurology doi: 10.1212/WNL.0b013e3181dad605 – volume: 12 start-page: e12053 year: 2020 ident: B5 article-title: Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy publication-title: Alzheimers Dement doi: 10.1002/dad2.12053 – volume: 62 start-page: 782 year: 2012 ident: B28 article-title: FSL publication-title: Neuroimage doi: 10.1016/j.neuroimage.2011.09.015 – volume: 89 start-page: 212 year: 1992 ident: B54 article-title: Magnetic resonance imaging of perfusion using spin inversion of arterial water publication-title: Proc. Natl. Acad. Sci. U. S. A doi: 10.1073/pnas.89.1.212 – volume: 51 start-page: 11 year: 2020 ident: B49 article-title: Glymphatic imaging using MRI publication-title: J. Magn. Reson. Imag doi: 10.1002/jmri.26892 – volume: 149 start-page: 351 year: 1987 ident: B20 article-title: MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging publication-title: Am. J. Roentgenol doi: 10.2214/ajr.149.2.351 – volume: 23 start-page: S208 year: 2004 ident: B46 article-title: Advances in functional and structural MR image analysis and implementation as FSL publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.07.051 – volume: 102 start-page: 1025 year: 2021 ident: B40 article-title: Fluid transport in the brain publication-title: Physiol Rev doi: 10.1152/physrev.00031.2020 – volume: 17 start-page: 825 year: 2002 ident: B27 article-title: Improved optimization for the robust and accurate linear registration and motion correction of brain images publication-title: Neuroimage doi: 10.1006/nimg.2002.1132 – volume: 2 start-page: a006338 year: 2012 ident: B33 article-title: Neurotoxicity of amyloid β-protein: synaptic and network dysfunction publication-title: Cold Spring Harb. Perspect. Med doi: 10.1101/cshperspect.a006338 – volume: 24 start-page: 1198 year: 2021 ident: B43 article-title: Revisiting the neurovascular unit publication-title: Nat. Neurosci doi: 10.1038/s41593-021-00904-7 |
| SSID | ssj0000330058 |
| Score | 2.3710449 |
| Snippet | In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling... In this pilot study we investigated microvascular impairment in cerebral small vessel disease (CSVD) patients using non-invasive arterial spin labeling (ASL)... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 871612 |
| SubjectTerms | Aging Neuroscience Alzheimer's disease arterial spin labeling arterial transit time Blood flow Cerebral blood flow cerebral small vessel disease Cerebrovascular disease clearance Dementia Magnetic resonance imaging Metabolism Microvasculature Neuroimaging Perfusion Spin labeling Substantia alba Substantia grisea Vascular diseases |
| SummonAdditionalLinks | – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwED_BQGgvfMPCBjIST0hhTZzYMS9TGUwg0anSEOwtsmNni5QlXdoh8Y_w93LnpIEitBce21xTJ3e-b_8O4JXgBt0MrsLCZg4DFKlDXWYizOJSuyRJXSm0HzYhj4-z01M1HxJuy6Gtcq0TvaK2bUE58n00JEIokabZweIypKlRVF0dRmjchFuEksB96958zLFMOIGx-9NwaFjDhIu0L2xiXKb2S5oDhBFiHL-hqCGKN0yTR_D_l9v5d_fkH-bo6N7_Psh9uDs4omzaS84DuOGah3BnNpTaH8HPGbXqrRtV2SdUG1VHqURWNWzeo7Eu2bdqdc4OXUfl55qdXOi6Zl8Jjrxm7_vSD-vLys72tFNqIa2IdoH3-ayNPw_PZvqsoeOUjMoJhAHi8B_9AKW3bMrmVd2uGLU8_ngMJ0cfvhx-DIchDmFBs6xDFBH0Ebg1pclKFRnhVKInFr0Wk-DuL0UZWy1L7uupjjIwRjnL0bhqxTV_AltN27gdYNxJq6PUxrLQCbfCaPwo8bYag3gbZQFM1tzLiwHfnMZs1DnGOcTw3DM8J4bnPcMDeD3-ZNGDe1xH_I5EYiQkXG7_Rdud5cM2z_EJMpPQjC6KXLU06J4qjUpSWEs4OAHsrYUiH5TFMv8tEQG8HC_jNqfajW5ce0U0MqEu0EwG8LSXv3ElPCW3UUYByA3J3Fjq5pWmOvdQ4hgc0Jy5Z9cvaxe26UVQ00Sk9mBr1V2553C7-L6qlt0Lv-d-AXVzNsk priority: 102 providerName: ProQuest |
| Title | Microvascular Impairment in Patients With Cerebral Small Vessel Disease Assessed With Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35663571 https://www.proquest.com/docview/2666696558 https://www.proquest.com/docview/2674009487 https://pubmed.ncbi.nlm.nih.gov/PMC9161030 https://doaj.org/article/3e38b46db20140a7b5619a4886dd9960 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1663-4365 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330058 issn: 1663-4365 databaseCode: DOA dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1663-4365 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000330058 issn: 1663-4365 databaseCode: M~E dateStart: 20090101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdgIMQL4nMERmUknpDCljjxB2_d6MQkUkUMQXmK7NhhkUI6tR0SL_wZ_L3c2WnVIgQvvFhqfU0d313uznf5HSEvODPgZjAV11Y6CFCEjnUjeSzTRrssy13DtW82IaZTOZupcqvVF9aEBXjgsHGHzDFpMux6hLGAFgYMvtIgdtxaRBbBpy94PVvBlH8GM4RhlyGNCVGYOmyw6w_Eg2n6CmOEJN0xRB6v_09O5u-1klvG5_QuuTN4jXQcVnuPXHP9fXKrGPLiD8jPAuvq1lWl9Ax0vF3guR9te1oG6NQl_dSuLuiJW2CuuKPnX3XX0Y-IHd7RNyFPQ0MO2NlAO8Z6zxZpL-E677TxL6_TQn_p8d1Himf_CNjh4B99t6PXdEzLtpuvKNYnfn9Izk8nH07exkPHhbjGxtMx8BMMOrOmMbJRieFOZfrIgothMlDVhjep1aJhPvnp8LjEKGcZWEKtmGaPyF4_791jQpkTVie5TUWtM2a50fBRwGU1RNw2kRE5Wm9-VQ9g5NgTo6sgKEF-VZ5fFfKrCvyKyMvNTy4DEsffiI-RoxtCBNH2X4BoVYNoVf8SrYgcrOWhGjR7WYFDw7nieQ738HwzDTqJiRbdu_kV0ogMSzaliMh-EJ_NSliOPp5IIiJ2BGtnqbszfXvhcb_Bk8emcE_-x709Jbdxu7AOIlEHZG-1uHLPyM3626pdLkbkupgJP8oRuXE8mZbvR17BYCzSEkfhxx8TmC_PivLzLwvqLdA |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD4aAwEv3C-BAUaCF6SwJU5sBwmhsjGtWltV2gR7InJiZ4sU0tJ2oP0RfgU_knOcpFCE9rYHHtucuq77-Vx8js8H8ELwDN0Mnvi5URYDFKl9XSjhq7DQNopiWwjtyCbkaKSOjpLxGvzs7sJQWWWnE52iNpOczsg30ZAIkYg4Vu-mX31ijaLsakeh0cBi3559x5Bt_ra_g__vyzDc_XC4vee3rAJ-TuTKPs4ZjRY3WZGpIgkyYZNIbxk0o1mEcCxEERotC-4SfJaOBLLEGo7aXidccxz1ElxGJyJUrlBwvDzRQXEi6aMID824H3ERN2lUjAKTzYJYhzAeDcPXFKME4YohdHwB_3Jy_67V_MP47d78v5btFtxonWzWa3bFbViz9R24OmzLCO7CjyGVIXZFuKyPKrGc0TEpK2s2bjrNztmncnHCtu2MUusVO_iiq4p9pFbrFdtp0lqsSZlb08j2qDy2JNkpjjPQmbvrz4b6uKarooxSJdTfxOI3OnKoN6zHxmU1WTAq5zy7BwcXsCb3Yb2e1PYhMG6l0UFsQpnriBuRaXwpcVitlDKB8mCrw0qat73biUKkSjGGI3ilDl4pwStt4OXBq-VHpk3jkvOE3xMAl4LUc9y9MZkdp60KS_EXqCwi_jGKyrXM0PVONBoAYQz1-PFgo4Ng2irCefobfx48Xz5GFUZ5KV3bySnJyIgqXJX04EGD9uVMeEwusQw8kCv7YGWqq0_q8sS1ScfAhzj0Hp0_rWdwbe9wOEgH_dH-Y7hOi0LFIUGyAeuL2al9Alfyb4tyPnvqdjuDzxe7S34BqaKRXA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9NAEB2VgioufH8YCiwSXJBMaq-9u0ZCKDRURG2iSEXQE9bau24tGSckKah_hN_Cz2NmbQeCUG89cEw8cTabtzM7O8_zAJ4JnuE2gyd-bpTFBEVqXxdK-CostI2i2BZCO7EJOR6ro6NksgE_u2dhiFbZ-UTnqM00pzPyHgYSIRIRx6pXtLSIyWDvzeyrTwpSVGnt5DQaiOzbs--Yvi1eDwf4Xz8Pw713H3bf-63CgJ-T0LKP48cAxk1WZKpIgkzYJNI7BkNqFiE0C1GERsuCu2KfpeOBLLGGo-fXCdcc73oJLktqWe5Ig5PV6Q6ak2AfZXsY0v2Ii7gpqWJGmPQKUiDC3DQMX1K-EoRrQdFpB_xrw_s3b_OPQLh3_f-dwhtwrd18s36zWm7Chq1vwdaopRfchh8joid25Fw2RFdZzun4lJU1mzQdaBfsU7k8Ybt2TiX3ih1-0VXFPlIL9ooNmnIXa0rp1jS2faLNlmQ7w_sc6Mz1AGAjfVzTI6SMSijU98TiNzrRqFeszyZlNV0yonme3YHDC5iTu7BZT2t7Hxi30uggNqHMdcSNyDS-lHhbrZQygfJgp8NNmrc93UlapEoxtyOopQ5qKUEtbaDmwYvVR2ZNQ5PzjN8SGFeG1IvcvTGdH6eta0vxF6gsIl0yyta1zHBLnmgMDMIY6v3jwXYHx7R1kIv0NxY9eLq6jK6N6lW6ttNTspERMV-V9OBeg_zVSHhMW2UZeCDX1sTaUNev1OWJa5-OCRFp6z04f1hPYAsXR3owHO8_hKs0J8QZCZJt2FzOT-0juJJ_W5aL-WO38Bl8vthF8gvWYZoZ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Microvascular+Impairment+in+Patients+With+Cerebral+Small+Vessel+Disease+Assessed+With+Arterial+Spin+Labeling+Magnetic+Resonance+Imaging%3A+A+Pilot+Study&rft.jtitle=Frontiers+in+aging+neuroscience&rft.au=Katja+Neumann&rft.au=Matthias+G%C3%BCnther&rft.au=Matthias+G%C3%BCnther&rft.au=Matthias+G%C3%BCnther&rft.date=2022-05-19&rft.pub=Frontiers+Media+S.A&rft.eissn=1663-4365&rft.volume=14&rft_id=info:doi/10.3389%2Ffnagi.2022.871612&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_3e38b46db20140a7b5619a4886dd9960 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1663-4365&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1663-4365&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1663-4365&client=summon |